Hai-Song Wang, Xin-Rui Ma, Yi-Hong Guo
Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 40 Daxue Road, 450052, Zhengzhou, Henan Province, China.
Stem Cell Res Ther. 2024 Apr 23;15(1):116. doi: 10.1186/s13287-024-03727-y.
Haploid cells are a kind of cells with only one set of chromosomes. Compared with traditional diploid cells, haploid cells have unique advantages in gene screening and drug-targeted therapy, due to their phenotype being equal to the genotype. Embryonic stem cells are a kind of cells with strong differentiation potential that can differentiate into various types of cells under specific conditions in vitro. Therefore, haploid embryonic stem cells have the characteristics of both haploid cells and embryonic stem cells, which makes them have significant advantages in many aspects, such as reproductive developmental mechanism research, genetic screening, and drug-targeted therapy. Consequently, establishing haploid embryonic stem cell lines is of great significance. This paper reviews the progress of haploid embryonic stem cell research and briefly discusses the applications of haploid embryonic stem cells.
单倍体细胞是一种仅含有一组染色体的细胞。与传统的二倍体细胞相比，单倍体细胞在基因筛选和药物靶向治疗方面具有独特优势，因为其表型等同于基因型。胚胎干细胞是一类具有强大分化潜能的细胞，在体外特定条件下可分化为各种类型的细胞。因此，单倍体胚胎干细胞兼具单倍体细胞和胚胎干细胞的特性，这使其在生殖发育机制研究、基因筛选和药物靶向治疗等诸多方面具有显著优势。所以，建立单倍体胚胎干细胞系具有重要意义。本文综述了单倍体胚胎干细胞的研究进展，并简要探讨了单倍体胚胎干细胞的应用。
