弥合差距：多民族人群中阿尔茨海默病与老年对照者脑组织的多组学分析

Bridging the Gap: Multi-Omics Profiling of Brain Tissue in Alzheimer's Disease and Older Controls in Multi-Ethnic Populations.

作者信息

Reddy Joseph S, Heath Laura, Vander Linden Abby, Allen Mariet, de Paiva Lopes Katia, Seifar Fatemeh, Wang Erming, Ma Yiyi, Poehlman William L, Quicksall Zachary S, Runnels Alexi, Wang Yanling, Duong Duc M, Yin Luming, Xu Kaiming, Modeste Erica S, Shantaraman Anantharaman, Dammer Eric B, Ping Lingyan, Oatman Stephanie R, Scanlan Jo, Ho Charlotte, Carrasquillo Minerva M, Atik Merve, Yepez Geovanna, Mitchell Adriana O, Nguyen Thuy T, Chen Xianfeng, Marquez David X, Reddy Hasini, Xiao Harrison, Seshadri Sudha, Mayeux Richard, Prokop Stefan, Lee Edward B, Serrano Geidy E, Beach Thomas G, Teich Andrew F, Haroutunian Varham, Fox Edward J, Gearing Marla, Wingo Aliza, Wingo Thomas, Lah James J, Levey Allan I, Dickson Dennis W, Barnes Lisa L, De Jager Philip, Zhang Bin, Bennett David, Seyfried Nicholas T, Greenwood Anna K, Ertekin-Taner Nilüfer

机构信息

Mayo Clinic Florida, 4500 San Pablo Rd S, Jacksonville, FL 32224.

Sage Bionetworks, 2901 3rd Ave #330, Seattle, WA 98121.

出版信息

bioRxiv. 2024 Apr 20:2024.04.16.589592. doi: 10.1101/2024.04.16.589592.

DOI:10.1101/2024.04.16.589592

PMID:38659743

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11042309/

Abstract

INTRODUCTION

Multi-omics studies in Alzheimer's disease (AD) revealed many potential disease pathways and therapeutic targets. Despite their promise of precision medicine, these studies lacked African Americans (AA) and Latin Americans (LA), who are disproportionately affected by AD.

METHODS

To bridge this gap, Accelerating Medicines Partnership in AD (AMP-AD) expanded brain multi-omics profiling to multi-ethnic donors.

RESULTS

We generated multi-omics data and curated and harmonized phenotypic data from AA (n=306), LA (n=326), or AA LA (n=4) brain donors plus Non-Hispanic White (n=252) and other (n=20) ethnic groups, to establish a foundational dataset enriched for AA and LA participants. This study describes the data available to the research community, including transcriptome from three brain regions, whole genome sequence, and proteome measures.

DISCUSSION

Inclusion of traditionally underrepresented groups in multi-omics studies is essential to discover the full spectrum of precision medicine targets that will be pertinent to all populations affected with AD.

摘要

引言

阿尔茨海默病（AD）的多组学研究揭示了许多潜在的疾病途径和治疗靶点。尽管这些研究有望实现精准医学，但它们缺乏非裔美国人（AA）和拉丁裔美国人（LA），而这两个群体受AD影响的比例过高。

方法

为了弥补这一差距，阿尔茨海默病加速药物合作组织（AMP-AD）将大脑多组学分析扩展到多民族捐赠者。

结果

我们生成了多组学数据，并整理和协调了来自非裔美国人（n = 306）、拉丁裔美国人（n = 326）或非裔美国人和拉丁裔美国人（n = 4）大脑捐赠者以及非西班牙裔白人（n = 252）和其他（n = 20）种族群体的表型数据，以建立一个富含非裔美国人和拉丁裔美国人参与者的基础数据集。本研究描述了可供研究界使用的数据，包括来自三个脑区的转录组、全基因组序列和蛋白质组测量值。