Department of Radiation Oncology, Mayo Clinic, Jacksonville, Florida, USA.
J Appl Clin Med Phys. 2024 May;25(5):e14366. doi: 10.1002/acm2.14366. Epub 2024 Apr 26.
Skin collimation is a useful tool in electron beam therapy (EBT) to decrease the penumbra at the field edge and minimize dose to nearby superficial organs at risk (OARs), but manually fabricating these collimation devices in the clinic to conform to the patient's anatomy can be a difficult and time intensive process. This work compares two types of patient-specific skin collimation (in-house 3D printed and vendor-provided machined brass) using clinically relevant metrics.
Attenuation measurements were performed to determine the thickness of each material needed to adequately shield both 6 and 9 MeV electron beams. Relative and absolute dose planes at various depths were measured using radiochromic film to compare the surface dose, flatness, and penumbra of the different skin collimation materials.
Clinically acceptable thicknesses of each material were determined for both 6 and 9 MeV electron beams. Field width, flatness, and penumbra results between the two systems were very similar and significantly improved compared to measurements performed with no surface collimation.
Both skin collimation methods investigated in this work generate sharp penumbras at the field edge and can minimize dose to superficial OARs compared to treatment fields with no surface collimation. The benefits of skin collimation are greatest for lower energy electron beams, and the benefits decrease as the measurement depth increases. Using bolus with skin collimation is recommended to avoid surface dose enhancement seen with collimators placed on the skin surface. Ultimately, the appropriate choice of material will depend on the desire to create these devices in-house or outsource the fabrication to a vendor.
在电子束治疗(EBT)中,皮肤准直是一种有用的工具,可减小射野边缘的半影,并最大限度地降低附近浅表危及器官(OAR)的剂量,但在临床中手动制造这些准直器以适应患者的解剖结构可能是一个困难且耗时的过程。本研究使用临床相关指标比较了两种患者特异性皮肤准直(内部 3D 打印和供应商提供的机械加工黄铜)。
进行衰减测量以确定每种材料的厚度,以充分屏蔽 6 和 9 MeV 电子束。使用光致变色胶片测量不同深度处的相对和绝对剂量平面,以比较不同皮肤准直材料的表面剂量、平坦度和半影。
确定了两种材料在 6 和 9 MeV 电子束下的临床可接受厚度。与无表面准直的测量相比,两个系统的射野宽度、平坦度和半影结果非常相似,且显著改善。
本研究中研究的两种皮肤准直方法都能在射野边缘产生锐利的半影,并能最大限度地降低无表面准直治疗野中浅表 OAR 的剂量。皮肤准直的益处对于较低能量的电子束最大,并且随着测量深度的增加而减小。建议使用敷贴与皮肤准直一起使用,以避免与放置在皮肤表面的准直器相关的表面剂量增强。最终,合适的材料选择将取决于在内部制造这些设备还是将制造外包给供应商的愿望。