髓性白血病中染色体改变的分子生物学
The molecular biology of chromosome alterations in myelogenous leukemia.
作者信息
Drabkin H A
出版信息
West J Med. 1985 Dec;143(6):825-8.
Abstract
In the past few years, new developments have rapidly emerged that promise to unravel the pathogenesis of malignant transformation. By understanding the molecular events in neoplastic transformation, such as in myelogenous leukemia, we should be able to devise specific and effective therapies and to intervene in the development of these diseases. Furthermore, the study of cancer genes is likely to have far-reaching effects with regard to our understanding of normal development and other nonneoplastic conditions.
摘要
在过去几年中，迅速出现了一些新进展，有望揭示恶性转化的发病机制。通过了解肿瘤转化过程中的分子事件，比如骨髓性白血病中的分子事件，我们应该能够设计出具体有效的治疗方法，并干预这些疾病的发展。此外，癌症基因的研究对于我们理解正常发育和其他非肿瘤性疾病可能会产生深远影响。
相似文献
1
The molecular biology of chromosome alterations in myelogenous leukemia.髓性白血病中染色体改变的分子生物学
West J Med. 1985 Dec;143(6):825-8.
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[Cytogenetics of Philadelphia-chromosome-positive leukemias].
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Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation.伴有t(11;14)染色体易位的B细胞淋巴瘤和白血病染色体断裂点的分子克隆
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A human c-erbA oncogene homologue is closely proximal to the chromosome 17 breakpoint in acute promyelocytic leukemia.一种人类c-erbA癌基因同源物紧邻急性早幼粒细胞白血病中17号染色体的断点。
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Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.c - ab1癌基因的易位与慢性粒细胞白血病中费城染色体的存在相关。
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Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.16号染色体倒位与急性粒单核细胞白血病异常骨髓嗜酸性粒细胞的关联。一种独特的细胞遗传学 - 临床病理关联。
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Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene.人类c-myc癌基因所表达蛋白质的核定位及DNA结合特性
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The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus.具有t(11;14)易位的肿瘤性B细胞中的14号染色体断点涉及免疫球蛋白重链基因座。
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