Gao Wanting, Lu Junjie, Yang Zitao, Li Enmin, Cao Yufei, Xie Lei
Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China.
Biomolecules. 2024 Mar 22;14(4):386. doi: 10.3390/biom14040386.
Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the formation and maintenance of the mitotic spindle. Recently, an increasing quantity of data have demonstrated the upregulated expression of KIF11 in various cancers, promoting the emergence and progression of cancers. This suggests the great potential of KIF11 as a prognostic biomarker and therapeutic target. However, the molecular mechanisms of KIF11 in cancers have not been systematically summarized. Therefore, we first discuss the functions of the protein encoded by KIF11 during mitosis and connect the abnormal expression of KIF11 with its clinical significance. Then, we elucidate the mechanism of KIF11 to promote various hallmarks of cancers. Finally, we provide an overview of KIF11 inhibitors and outline areas for future work.
有丝分裂介导子细胞的精确分离，而异常情况与癌症进展密切相关。驱动蛋白家族成员KIF11在有丝分裂纺锤体的形成和维持中起着至关重要的作用。最近，越来越多的数据表明KIF11在各种癌症中表达上调，促进了癌症的发生和发展。这表明KIF11作为一种预后生物标志物和治疗靶点具有巨大潜力。然而，KIF11在癌症中的分子机制尚未得到系统总结。因此，我们首先讨论KIF11编码的蛋白质在有丝分裂过程中的功能，并将KIF11的异常表达与其临床意义联系起来。然后，我们阐明KIF11促进癌症各种特征的机制。最后，我们概述了KIF11抑制剂，并概述了未来工作的方向。
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