Wang Wenbo, Pan Da, Liu Qi, Chen Xiangjun, Wang Shaokang
Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Department of Public Health, School of Medicine, Xizang Minzu University, Xianyang 712082, China.
Nutrients. 2024 Apr 20;16(8):1232. doi: 10.3390/nu16081232.
L-carnitine (LC), a vital nutritional supplement, plays a crucial role in myocardial health and exhibits significant cardioprotective effects. LC, being the principal constituent of clinical-grade supplements, finds extensive application in the recovery and treatment of diverse cardiovascular and cerebrovascular disorders. However, controversies persist regarding the utilization of LC in nervous system diseases, with varying effects observed across numerous mental and neurological disorders. This article primarily aims to gather and analyze database information to comprehensively summarize the therapeutic potential of LC in patients suffering from nervous system diseases while providing valuable references for further research.
A comprehensive search was conducted in PubMed, Web Of Science, Embase, Ovid Medline, Cochrane Library and Clinicaltrials.gov databases. The literature pertaining to the impact of LC supplementation on neurological or psychiatric disorders in patients was reviewed up until November 2023. No language or temporal restrictions were imposed on the search.
A total of 1479 articles were retrieved, and after the removal of duplicates through both automated and manual exclusion processes, 962 articles remained. Subsequently, a meticulous re-screening led to the identification of 60 relevant articles. Among these, there were 12 publications focusing on hepatic encephalopathy (HE), while neurodegenerative diseases (NDs) and peripheral nervous system diseases (PNSDs) were represented by 9 and 6 articles, respectively. Additionally, stroke was addressed in five publications, whereas Raynaud's syndrome (RS) and cognitive disorder (CD) each had three dedicated studies. Furthermore, migraine, depression, and amyotrophic lateral sclerosis (ALS) each accounted for two publications. Lastly, one article was found for other symptoms under investigation.
In summary, LC has demonstrated favorable therapeutic effects in the management of HE, Alzheimer's disease (AD), carpal tunnel syndrome (CTS), CD, migraine, neurofibromatosis (NF), PNSDs, RS, and stroke. However, its efficacy appears to be relatively limited in conditions such as ALS, ataxia, attention deficit hyperactivity disorder (ADHD), depression, chronic fatigue syndrome (CFS), Down syndrome (DS), and sciatica.
左旋肉碱（LC）作为一种重要的营养补充剂，对心肌健康起着关键作用，并具有显著的心脏保护作用。LC作为临床级补充剂的主要成分，广泛应用于各种心脑血管疾病的康复和治疗。然而，关于LC在神经系统疾病中的应用仍存在争议，在众多精神和神经疾病中观察到的效果各不相同。本文主要旨在收集和分析数据库信息，全面总结LC对神经系统疾病患者的治疗潜力，为进一步研究提供有价值的参考。
在PubMed、Web of Science、Embase、Ovid Medline、Cochrane Library和Clinicaltrials.gov数据库中进行了全面检索。截至2023年11月，对有关补充LC对患者神经或精神疾病影响的文献进行了综述。检索没有语言或时间限制。
共检索到1479篇文章，通过自动和手动排除重复文章后，剩余962篇。随后，经过细致的重新筛选，确定了60篇相关文章。其中，有12篇出版物聚焦于肝性脑病（HE），而神经退行性疾病（NDs）和周围神经系统疾病（PNSDs）分别有9篇和6篇文章。此外，有5篇出版物涉及中风，而雷诺综合征（RS）和认知障碍（CD）各有3项专门研究。此外，偏头痛、抑郁症和肌萎缩侧索硬化症（ALS）各占2篇出版物。最后，发现1篇文章涉及其他正在研究的症状。
总之，LC在治疗HE、阿尔茨海默病（AD）、腕管综合征（CTS）、CD、偏头痛、神经纤维瘤病（NF）、PNSDs、RS和中风方面已显示出良好的治疗效果。然而，在ALS、共济失调、注意力缺陷多动障碍（ADHD）、抑郁症、慢性疲劳综合征（CFS）、唐氏综合征（DS）和坐骨神经痛等疾病中，其疗效似乎相对有限。
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