Department of Neurosurgery, The Translational Research Institute for Neurological Disorders, The First Affiliated Hospital (Yijishan Hospital), Wannan Medical College, Wuhu, P. R. China.
Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.
Gliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. More and more studies have shown that TRPM channels can be used as new therapeutic targets for glioma. In this review, we first introduce the structure, activation patterns, and physiological functions of TRPM channels. Additionally, the pathological mechanism of glioma mediated by TRPM2, 3, 7, and 8 and the related signaling pathways are described. Finally, we discuss the therapeutic potential of targeting TRPM for glioma.
神经胶质瘤是最常见的原发性脑肿瘤。尽管在治疗方面取得了进展，但它仍然是中枢神经系统（CNS）中最具侵袭性和致命性的肿瘤之一。神经胶质瘤的特点是恶性程度高、异质性、侵袭性和对放疗和化疗的高度耐药性。迫切需要寻找潜在的新的神经胶质瘤分子靶点。瞬时受体电位阳离子通道亚家族 M 成员 1-8（TRPM）通道由 TRPM1-TRPM8 组成，在许多细胞功能中发挥作用，包括增殖、迁移、侵袭、血管生成等。越来越多的研究表明，TRPM 通道可以作为神经胶质瘤的新治疗靶点。在这篇综述中，我们首先介绍了 TRPM 通道的结构、激活模式和生理功能。此外，还描述了 TRPM2、3、7 和 8 介导的神经胶质瘤的病理机制及相关信号通路。最后，我们讨论了针对 TRPM 治疗神经胶质瘤的治疗潜力。
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