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组学技术在反刍动物中用于了解热带植物源生物活性化合物的应用:综述

The application of omics technologies for understanding tropical plants-based bioactive compounds in ruminants: a review.

作者信息

Wanapat Metha, Dagaew Gamonmas, Sommai Sukruthai, Matra Maharach, Suriyapha Chaichana, Prachumchai Rittikeard, Muslykhah Uswatun, Phupaboon Srisan

机构信息

Tropical Feed Resources Research and Development Center (TROFREC), Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen, 40002, Thailand.

Department of Animal Science, Faculty of Agricultural Technology, University of Technology Thanyaburi, Rajamangala Pathum Thani, 12130, Thailand.

出版信息

J Anim Sci Biotechnol. 2024 May 1;15(1):58. doi: 10.1186/s40104-024-01017-4.

Abstract

Finding out how diet impacts health and metabolism while concentrating on the functional qualities and bioactive components of food is the crucial scientific objective of nutritional research. The complex relationship between metabolism and nutrition could be investigated with cutting-edge "omics" and bioinformatics techniques. This review paper provides an overview of the use of omics technologies in nutritional research, with a particular emphasis on the new applications of transcriptomics, proteomics, metabolomics, and genomes in functional and biological activity research on ruminant livestock and products in the tropical regions. A wealth of knowledge has been uncovered regarding the regulation and use of numerous physiological and pathological processes by gene, mRNA, protein, and metabolite expressions under various physiological situations and guidelines. In particular, the components of meat and milk were assessed using omics research utilizing the various methods of transcriptomics, proteomics, metabolomics, and genomes. The goal of this review is to use omics technologies-which have been steadily gaining popularity as technological tools-to develop new nutritional, genetic, and leadership strategies to improve animal products and their quality control. We also present an overview of the new applications of omics technologies in cattle production and employ nutriomics and foodomics technologies to investigate the microbes in the rumen ecology. Thus, the application of state-of-the-art omics technology may aid in our understanding of how species and/or breeds adapt, and the sustainability of tropical animal production, in the long run, is becoming increasingly important as a means of mitigating the consequences of climate change.

摘要

在关注食物的功能特性和生物活性成分的同时,弄清楚饮食如何影响健康和新陈代谢是营养研究的关键科学目标。新陈代谢与营养之间的复杂关系可以通过前沿的“组学”和生物信息学技术进行研究。本文综述了组学技术在营养研究中的应用,特别强调了转录组学、蛋白质组学、代谢组学和基因组学在热带地区反刍家畜及其产品功能和生物活性研究中的新应用。在各种生理状况和指导原则下,通过基因、mRNA、蛋白质和代谢物表达对众多生理和病理过程的调控和利用方面,已经发现了大量知识。特别是,利用转录组学、蛋白质组学、代谢组学和基因组学的各种方法,通过组学研究评估了肉和奶的成分。本综述的目的是利用作为技术工具正逐渐受到欢迎的组学技术,制定新的营养、遗传和管理策略,以改善动物产品及其质量控制。我们还概述了组学技术在养牛生产中的新应用,并采用营养组学和食品组学技术研究瘤胃生态中的微生物。因此,应用最先进的组学技术可能有助于我们理解物种和/或品种的适应方式,从长远来看,热带动物生产的可持续性作为减轻气候变化影响的一种手段正变得越来越重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96b0/11062008/71d968bf484e/40104_2024_1017_Fig1_HTML.jpg

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