Neurosurgery Department, Medical College of Georgia, Augusta, GA, USA.
Geroscience. 2024 Dec;46(6):6537-6561. doi: 10.1007/s11357-024-01173-5. Epub 2024 May 1.
Chronic subdural hematoma (cSDH) is one of the most prevalent neurosurgical diseases, especially in the elderly. Yet, its incidence is predicted to increase further, paralleling the growth of the geriatric population. While surgical evacuation is technically straightforward, it is associated with significant morbidity and mortality. In fact, 30% of patients are expected to have hematoma recurrence and to need repeat surgical evacuation, and 20% of patients are expected to lose independence and require long-term care. A pathophysiology more complex than originally presumed explains the disappointing results observed for decades. At its core, the formation of microcapillaries and anastomotic channels with the middle meningeal artery (MMA) perpetuates a constant cycle resulting in persistence of hematoma. The rationale behind MMA embolization is simple: to stop cSDH at its source. Over the last few years, this "newer" option has been heavily studied. It has shown tremendous potential in decreasing hematoma recurrence and improving neurological outcomes. Whether combined with surgical evacuation or performed as the only treatment, the scientific evidence to its benefits is unequivocal. Here, we aimed to review cSDH in the elderly and discuss its more recent treatment options with an emphasis on MMA embolization.
慢性硬脑膜下血肿(cSDH)是最常见的神经外科疾病之一,尤其在老年人中更为常见。然而,随着老年人口的增长,预计其发病率将进一步上升。虽然手术清除血肿在技术上较为简单,但它与显著的发病率和死亡率相关。事实上,30%的患者预计会出现血肿复发,需要再次手术清除,20%的患者预计会失去独立性并需要长期护理。几十年来,观察到的令人失望的结果表明,其病理生理学比最初假设的更为复杂。其核心是微毛细血管和吻合通道与脑膜中动脉(MMA)的形成,使血肿持续存在。MMA 栓塞的基本原理很简单:从源头阻止 cSDH 的发生。在过去的几年中,这种“更新”的选择已经得到了广泛的研究。它在降低血肿复发率和改善神经功能预后方面显示出巨大的潜力。无论是与手术清除联合应用,还是作为唯一的治疗方法,其获益的科学证据是明确的。在这里,我们旨在回顾老年人的 cSDH,并讨论其最近的治疗选择,重点介绍 MMA 栓塞。