Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Center for Advanced Manufacturing, University of Southern California, Los Angeles, CA, USA.
Sci Adv. 2024 May 3;10(18):eadn7202. doi: 10.1126/sciadv.adn7202. Epub 2024 May 1.
Stretchable three-dimensional (3D) penetrating microelectrode arrays have potential utility in various fields, including neuroscience, tissue engineering, and wearable bioelectronics. These 3D microelectrode arrays can penetrate and conform to dynamically deforming tissues, thereby facilitating targeted sensing and stimulation of interior regions in a minimally invasive manner. However, fabricating custom stretchable 3D microelectrode arrays presents material integration and patterning challenges. In this study, we present the design, fabrication, and applications of stretchable microneedle electrode arrays (SMNEAs) for sensing local intramuscular electromyography signals ex vivo. We use a unique hybrid fabrication scheme based on laser micromachining, microfabrication, and transfer printing to enable scalable fabrication of individually addressable SMNEA with high device stretchability (60 to 90%). The electrode geometries and recording regions, impedance, array layout, and length distribution are highly customizable. We demonstrate the use of SMNEAs as bioelectronic interfaces in recording intramuscular electromyography from various muscle groups in the buccal mass of .
可拉伸的三维（3D）穿透微电极阵列在神经科学、组织工程和可穿戴生物电子学等各个领域具有潜在的应用价值。这些 3D 微电极阵列可以穿透并顺应动态变形的组织，从而以微创的方式实现对内部区域的靶向感应和刺激。然而，制造定制的可拉伸 3D 微电极阵列面临着材料集成和图案化的挑战。在本研究中，我们提出了用于体外感应局部肌内肌电图信号的可拉伸微针电极阵列（SMNEA）的设计、制造和应用。我们使用了一种独特的混合制造方案，基于激光微加工、微制造和转印技术，实现了可伸缩性高（60% 到 90%）的、可单独寻址的 SMNEA 的可扩展制造。电极几何形状和记录区域、阻抗、阵列布局和长度分布具有高度的可定制性。我们展示了 SMNEA 作为生物电子接口在记录颊肌中各种肌肉群的肌内肌电图中的应用。
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