打破组蛋白供应的平衡会使基因组稳定性受到威胁。

Tipping the balance in histone supply puts genome stability at stake.

机构信息

Institut Curie, CNRS, PSL Research University, Sorbonne University, Nuclear Dynamics Unit, Équipe Labellisée Ligue contre le Cancer, Paris, France.

出版信息

EMBO J. 2024 Jun;43(11):2091-2093. doi: 10.1038/s44318-024-00112-6. Epub 2024 May 2.

DOI:10.1038/s44318-024-00112-6

PMID:38698217

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11148134/

Abstract

Specific localization of the histone H3 variant CENP-A at centromeres is key for faithful chromosome segregation during cell division, with CENP-A mislocalization being associated with chromosomal instability and cancer. New work in identifies the H3-H4 chaperone DNAJC9 as a factor restricting CENP-A localization, underscoring the importance of balancing H3 and CENP-A histone levels for ensuring proper CENP-A localization and maintaining genome stability.

摘要

特定组蛋白 H3 变体 CENP-A 在着丝粒处的特异性定位是细胞分裂过程中染色体正确分离的关键，CENP-A 的定位错误与染色体不稳定和癌症有关。在[文献标题]中发现，H3-H4 伴侣蛋白 DNAJC9 是限制 CENP-A 定位的一个因素，这突显了平衡 H3 和 CENP-A 组蛋白水平对于确保正确的 CENP-A 定位和维持基因组稳定性的重要性。