School of Veterinary Medicine, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
School of Veterinary Medicine, Department of Medical Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.
J Vet Intern Med. 2024 Jul-Aug;38(4):2339-2343. doi: 10.1111/jvim.17090. Epub 2024 May 4.
An 11-year-old female spayed German Wirehaired Pointer with a 1-week history of lethargy, hyporexia, diarrhea, and coughing presented with pericardial effusion causing cardiac tamponade. An echocardiogram revealed no structural cause for pericardial effusion. The pericardial effusion was an exudate with mixed macrophagic and neutrophilic inflammation. Morulae occasionally were found within neutrophils. The pericardial fluid and blood were qPCR and cPCR positive for Anaplasma phagocytophilum (NC State University, Vector-borne Disease Diagnostic Laboratory, Raleigh, NC). The dog's blood was negative by ELISA (Vetscan Flex4 Rapid Test, Zoetis, Parsippany, NJ) for A. phagocytophilum antibodies at initial presentation and subsequently positive (SNAP4DxPlus, IDEXX, Westbrook, ME) 7 days later. After pericardiocentesis and administration of doxycycline (5 mg/kg PO q12h for 14 days), a repeat echocardiogram performed 1 month later showed no recurrence of pericardial effusion.
一只 11 岁已绝育的雌性德国短毛指示猎犬，出现精神沉郁、食欲下降、腹泻和咳嗽 1 周，伴有心包积液导致的心包填塞。超声心动图未发现心包积液的结构性原因。心包积液为渗出液，伴混合巨噬细胞和中性粒细胞炎症。中性粒细胞内偶尔可见芽殖体。心包液和血液 qPCR 和 cPCR 检测嗜吞噬细胞无形体阳性（北卡罗来纳州立大学，Vector-borne Disease Diagnostic Laboratory，Raleigh，NC）。该犬初诊时血液 ELISA（Vetscan Flex4 Rapid Test，Zoetis，Parsippany，NJ）检测嗜吞噬细胞无形体抗体阴性，随后 7 天后阳性（SNAP4DxPlus，IDEXX，Westbrook，ME）。心包穿刺和多西环素（5mg/kg PO q12h，连用 14 天）治疗后，1 个月后重复超声心动图检查未见心包积液复发。
