成人银屑病的眼部并发症：巴西转诊中心的一项横断面研究。
Ocular complications in adults with psoriasis: a cross-sectional study in a referral center in Brazil.
机构信息
University Hospital Complex Professor Edgard Santos (HUPES) - Federal University of Bahia, Salvador, Brazil.
Bahiana School of Medicine and Public Health, Rua Machado Neto, 129, Pituba, Salvador, Bahia, CEP 41830-510, Brazil.
出版信息
Int Ophthalmol. 2024 May 5;44(1):215. doi: 10.1007/s10792-024-03147-0.
PURPOSE
There is limited literature on the ocular manifestations in patients with psoriasis. Therefore, this study aimed to identify the prevalence of and factors associated with ocular manifestations in adults with psoriasis.
METHODS
This cross-sectional study included Brazilian adults with psoriasis. The dermatological evaluation included diagnosis, clinical form, Psoriasis Area and Severity Index (PASI) measurement, and location of the lesions. Patients underwent a full ophthalmological examination, including the Schirmer I test, Rose Bengala staining, and tear breakup time tests. The results were analyzed using chi-square and Pearson's linear correlation tests.
RESULTS
Of the 130 patients assessed, 118 (90.8%) exhibited ocular abnormalities, with meibomian gland dysfunction (MGD) being the most prevalent (59.2%), followed by dry eye disease (DED) (56.2%). A significant correlation was observed between MGD and PASI (p = 0.05), and between MGD and certain treatment modalities. DED was significantly associated with PASI (p < 0.05). Concurrent use of acitretin was identified as an independent predictor of MGD (odds ratio [OR] = 3.5, p < 0.05), whereas PASI was a protective factor against DED (OR = 0.39, p < 0.01).
CONCLUSION
Given the high prevalence of eye disease among individuals with psoriasis, routine ophthalmological assessments are recommended to prevent possible ocular complications.
目的
有关银屑病患者眼部表现的文献有限。因此，本研究旨在确定成人银屑病患者眼部表现的患病率和相关因素。
方法
本横断面研究纳入了巴西成年银屑病患者。皮肤科评估包括诊断、临床类型、银屑病面积和严重程度指数（PASI）测量以及病变部位。患者接受全面的眼科检查，包括 Schirmer I 试验、Rose Bengal 染色和泪膜破裂时间试验。使用卡方检验和 Pearson 线性相关检验对结果进行分析。
结果
在评估的 130 名患者中，118 名（90.8%）存在眼部异常，其中睑板腺功能障碍（MGD）最为常见（59.2%），其次是干眼症（DED）（56.2%）。MGD 与 PASI 之间存在显著相关性（p=0.05），并且与某些治疗方式之间存在相关性。DED 与 PASI 显著相关（p<0.05）。阿维 A 酯的同时使用被确定为 MGD 的独立预测因子（比值比[OR] = 3.5，p<0.05），而 PASI 是 DED 的保护因素（OR = 0.39，p<0.01）。
结论
鉴于银屑病患者眼部疾病的高患病率，建议进行常规眼科评估以预防可能的眼部并发症。
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