天然产物防治肌萎缩侧索硬化症（ALS）的研究进展。
Insights on Natural Products Against Amyotrophic Lateral Sclerosis (ALS).
机构信息
Research Group on Therapeutic Strategies - GPET, Laboratory of Synthesis and Research in Medicinal Chemistry - LSPMED, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceió, Alagoas, Brazil.
Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceió, Brazil.
出版信息
Curr Neuropharmacol. 2024;22(7):1169-1188. doi: 10.2174/1570159X22666231016153606.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes the death of motor neurons and consequent muscle paralysis. Despite many efforts to address it, current therapy targeting ALS remains limited, increasing the interest in complementary therapies. Over the years, several herbal preparations and medicinal plants have been studied to prevent and treat this disease, which has received remarkable attention due to their blood-brain barrier penetration properties and low toxicity. Thus, this review presents the therapeutic potential of a variety of medicinal herbs and their relationship with ALS and their physiopathological pathways.
肌萎缩侧索硬化症（ALS）是一种进行性神经退行性疾病，会导致运动神经元死亡和随后的肌肉瘫痪。尽管人们做出了许多努力来解决这个问题，但目前针对 ALS 的治疗方法仍然有限，这增加了人们对补充疗法的兴趣。多年来，人们研究了多种草药制剂和药用植物来预防和治疗这种疾病，由于其具有穿透血脑屏障的特性和低毒性，因此受到了极大的关注。因此，本综述介绍了各种药用植物的治疗潜力及其与 ALS 的关系，以及它们的生理病理途径。
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