Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.
Carbohydr Polym. 2024 Aug 1;337:122143. doi: 10.1016/j.carbpol.2024.122143. Epub 2024 Apr 10.
Cyclodextrins (CDs) are essential in the pharmaceutical industry and have long been used as food and pharmaceutical additives. CD-based interlocked molecules, such as rotaxanes, polyrotaxanes, catenanes, and polycatenanes, have been synthesized and have attracted considerable attention in supramolecular chemistry. Among them, CD polyrotaxanes have been employed as slide-ring materials and biomaterials. CD polycatenanes are new materials; therefore, to date, no examples of applied research on CD polycatenanes have been reported. Consequently, we expect that applied research on CD polycatenanes will accelerate in the future. This review article summarizes the syntheses and structural analyses of CD polyrotaxanes and polycatenanes to facilitate their applications in the pharmaceutical industry. We believe that this review will promote further research on CD-based interlocked molecules.
环糊精（CDs）在制药行业中至关重要，长期以来一直被用作食品和药物添加剂。基于 CD 的互锁分子，如轮烷、聚轮烷、索烃和超索烃，已经被合成，并在超分子化学中引起了相当大的关注。其中，CD 聚轮烷已被用作滑环材料和生物材料。CD 超索烃是新型材料；因此，迄今为止，尚未有关于 CD 超索烃应用研究的报道。因此，我们预计未来对 CD 超索烃的应用研究将会加速。本文综述了 CD 聚轮烷和超索烃的合成和结构分析，以促进其在制药行业中的应用。我们相信，这篇综述将促进基于 CD 的互锁分子的进一步研究。
