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嗜铬细胞瘤所致复发性Takotsubo心肌病经静脉-动脉体外膜肺氧合治疗

Recurrent Takotsubo Cardiomyopathy due to Pheochromocytoma Managed With Venoarterial Extracorporeal Membrane Oxygenation.

作者信息

Karmioti Georgia, Sakellaropoulos Stefanos, Sarikaya Inan, Kastoris Antonia, Hadjilouka Christina, Efseviou Christos, Myrianthefs Michael, Mitsis Andreas

机构信息

Cardiology Department, Nicosia General Hospital, Nicosia, Cyprus.

Department of Internal Medicine, Cardiology Clinic, Kantonsspital Baden, Baden, Switzerland.

出版信息

J Med Cases. 2024 May;15(4-5):72-77. doi: 10.14740/jmc4195. Epub 2024 May 2.

Abstract

Pheochromocytoma-induced Takotsubo cardiomyopathy is a rare but life-threatening condition, caused by excessive plasma catecholamine levels, resulting in acute myocardial dysfunction. Clinical presentation includes a rapid development of heart failure due to regional wall motion abnormalities (most commonly affecting all mid to apical left ventricle (LV) wall segments) causing the "octopus-trap-like" LV shape. A 45-year-old female patient presented with acute cardiogenic shock of non-ischemic etiology. Her past medical history included a similar episode, which was followed by full recovery, but at this admission she required hemodynamic support with venoarterial extracorporeal membrane oxygenation. The systolic function was restored, and further investigation revealed high 24-h urine metanephrine levels and a mass of the left adrenal gland, leading to the diagnosis of pheochromocytoma. After treatment with firstly alpha-blockers and then beta-blockers, the pheochromocytoma was surgically removed.

摘要

嗜铬细胞瘤诱发的应激性心肌病是一种罕见但危及生命的疾病,由血浆儿茶酚胺水平过高引起,导致急性心肌功能障碍。临床表现包括因局部室壁运动异常(最常见的是影响左心室(LV)所有中至心尖段室壁)导致“章鱼笼样”LV形状,从而迅速发展为心力衰竭。一名45岁女性患者出现非缺血性病因的急性心源性休克。她既往病史中有过类似发作,随后完全康复,但此次入院时她需要静脉-动脉体外膜肺氧合进行血流动力学支持。收缩功能得以恢复,进一步检查发现24小时尿间甲肾上腺素水平升高以及左肾上腺有肿物,从而诊断为嗜铬细胞瘤。先用α受体阻滞剂然后用β受体阻滞剂治疗后,手术切除了嗜铬细胞瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f37/11073464/a949d518e678/jmc-15-072-g001.jpg

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