Department of Plastic Surgery, The First Hospital of China Medical University, 110001 Shenyang, Liaoning Province, PR China.
ACS Biomater Sci Eng. 2024 Jun 10;10(6):3514-3527. doi: 10.1021/acsbiomaterials.3c01713. Epub 2024 May 9.
The field of bone regeneration has always been a hot and difficult research area, and there is no perfect strategy at present. As a new type of biodegradable material, magnesium alloys have excellent mechanical properties and bone promoting ability. Compared with other inert metals, magnesium alloys have significant advantages and broad application prospects in the field of bone regeneration. By searching the official Web sites and databases of various funds, this paper summarizes the research status of magnesium composites in the field of bone regeneration and introduces the latest scientific research achievements and clinical transformations of scholars in various countries and regions, such as improving the corrosion resistance of magnesium alloys by adding coatings. Finally, this paper points out the current problems and challenges, aiming to provide ideas and help for the development of new strategies for the treatment of bone defects and fractures.
骨再生领域一直是一个热门且极具难度的研究领域,目前尚无完美的策略。作为一种新型的可生物降解材料,镁合金具有优异的机械性能和骨诱导能力。与其他惰性金属相比,镁合金在骨再生领域具有显著的优势和广阔的应用前景。通过检索各类基金的官方网站和数据库,本文综述了镁基复合材料在骨再生领域的研究现状,介绍了各国学者在提高镁合金耐腐蚀性、添加涂层等方面的最新科研成果和临床转化,最后指出目前存在的问题和挑战,以期为治疗骨缺损和骨折的新策略的发展提供思路和帮助。