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DNA damage response genes as biomarkers of therapeutic outcomes in acute myeloid leukemia patients.

作者信息

Karami Adam, Skorski Tomasz

机构信息

Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.

出版信息

Leukemia. 2024 Jun;38(6):1407-1410. doi: 10.1038/s41375-024-02269-9. Epub 2024 May 11.

DOI:10.1038/s41375-024-02269-9
PMID:38734788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147752/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ee/11147752/19ab95df0af9/41375_2024_2269_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ee/11147752/7beeb94cd573/41375_2024_2269_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ee/11147752/19ab95df0af9/41375_2024_2269_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ee/11147752/7beeb94cd573/41375_2024_2269_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e4ee/11147752/19ab95df0af9/41375_2024_2269_Fig2_HTML.jpg

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Blood. 2023 May 11;141(19):2372-2389. doi: 10.1182/blood.2022018428.
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Integrative analysis of drug response and clinical outcome in acute myeloid leukemia.急性髓系白血病药物反应与临床结局的综合分析。
Cancer Cell. 2022 Aug 8;40(8):850-864.e9. doi: 10.1016/j.ccell.2022.07.002. Epub 2022 Jul 21.
3
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.
一种用于理解急性髓系白血病异质性和预测药物反应的细胞层次结构框架。
Nat Med. 2022 Jun;28(6):1212-1223. doi: 10.1038/s41591-022-01819-x. Epub 2022 May 26.
4
Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia.克隆结构可预测急性髓系白血病的临床结果和药物敏感性。
Nat Commun. 2021 Dec 13;12(1):7244. doi: 10.1038/s41467-021-27472-5.
5
DNA Polymerase θ: A Cancer Drug Target with Reverse Transcriptase Activity.DNA 聚合酶 θ:一种具有逆转录酶活性的癌症药物靶点。
Genes (Basel). 2021 Jul 27;12(8):1146. doi: 10.3390/genes12081146.
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A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.一种一流的聚合酶θ抑制剂选择性靶向同源重组缺陷型肿瘤。
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