用于药物动力学超分辨率成像的分子探针。
Molecular probes for super-resolution imaging of drug dynamics.
机构信息
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China.
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China; College of Life Science and Chemistry, Jiangsu Key Laboratory of Biological Functional Molecules, Jiangsu Second Normal University, Nanjing, Jiangsu 210013, China.
出版信息
Adv Drug Deliv Rev. 2024 Jul;210:115330. doi: 10.1016/j.addr.2024.115330. Epub 2024 May 10.
Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.
超分辨率分子探针（SRMPs）是可视化细胞内药物动态的重要工具，突破了传统显微镜的分辨率限制。在这篇综述中，我们概述了 SRMPs 的原理和设计策略，强调了它们在准确跟踪药物分子方面的作用。通过在亚细胞和分子水平上照亮药物分布、扩散、摄取和代谢的复杂过程，SRMPs 为治疗干预提供了关键的见解。此外，我们还探讨了超分辨率成像在疾病治疗中的实际应用，强调了 SRMPs 在推进我们对药物作用的理解方面的重要性。最后，我们讨论了未来的展望，设想了该领域的潜在进展和创新。总的来说，本综述旨在为研究人员和从业人员提供有关 SRMPs 在推动药理学创新和进展方面的效用的信息，为药物开发和优化提供有价值的见解。
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