通过金属配合物进行焦磷酸盐的选择性检测。
Selective pyrophosphate detection via metal complexes.
作者信息
Zhang Xiao, Sun Wenwen, Wang Le, Xie Zeping, Liu Mengxia, Wang Junfeng
机构信息
College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 125 Nashua Street, Suite 660, Boston, Massachusetts 02114, USA.
出版信息
iRadiology. 2023 Dec;1(4):320-339. doi: 10.1002/ird3.42. Epub 2023 Nov 21.
Pyrophosphate (PPi) anions are crucial in numerous biological and ecological processes involved in energy conversion, enzymatic reactions, and metabolic regulation along with adenosine. They are also significant biological markers for various processes related to diseases. Fluorescent PPi sensors would enable visual and/or biological detection in convenient settings. However, the current availability of commercial sensors has been limited to costly enzymes that are not compatible for imaging. Sensor development has also encountered challenges such as poor selectivity and stability, and limited practical applications. In this review, we analyze the situation of PPi sensing via commercial kits and focus on sensors that use metal complexes. We address their designs, sensing mechanisms, selectivities and detection limits. Finally, we discuss limitations and perspectives for PPi detection and imaging.
焦磷酸（PPi）阴离子在众多涉及能量转换、酶促反应和代谢调节的生物及生态过程中与腺苷一样至关重要。它们也是与疾病相关的各种过程的重要生物标志物。荧光PPi传感器能够在便捷的环境中进行可视化和/或生物检测。然而，目前市售传感器仅限于成本高昂且不适合成像的酶。传感器的开发还面临着选择性和稳定性差以及实际应用有限等挑战。在本综述中，我们分析了通过商业试剂盒进行PPi传感的情况，并重点关注使用金属配合物的传感器。我们阐述了它们的设计、传感机制、选择性和检测限。最后，我们讨论了PPi检测和成像的局限性及前景。
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