Mao Zi-Hui, Gao Zhong-Xiuzi, Pan Shao-Kang, Liu Dong-Wei, Liu Zhang-Suo, Wu Peng
Traditional Chinese Medicine Integrated Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.
Institute of Nephrology, Zhengzhou University, Zhengzhou, PR China.
Cell Death Discov. 2024 May 15;10(1):234. doi: 10.1038/s41420-024-02000-8.
Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients and energy to the host, but also plays a crucial role in immune modulation and metabolic balance. In this review, we explore the metabolic pathways associated with ferroptosis and the impact of the gut microbiota on host metabolism. We subsequently summarize recent studies on the influence and regulation of ferroptosis by the gut microbiota and discuss potential mechanisms through which the gut microbiota affects ferroptosis. Additionally, we conduct a bibliometric analysis of the relationship between the gut microbiota and ferroptosis in the context of chronic kidney disease. This analysis can provide new insights into the current research status and future of ferroptosis and the gut microbiota.
铁死亡是一种由脂质过氧化驱动、铁依赖性的新型程序性细胞死亡形式。包括脂质和铁代谢相关途径在内的各种代谢途径都参与铁死亡的调控。肠道微生物群不仅为宿主提供营养和能量，还在免疫调节和代谢平衡中发挥关键作用。在这篇综述中，我们探讨了与铁死亡相关的代谢途径以及肠道微生物群对宿主代谢的影响。随后，我们总结了肠道微生物群对铁死亡的影响和调控的最新研究，并讨论了肠道微生物群影响铁死亡的潜在机制。此外，我们对慢性肾脏病背景下肠道微生物群与铁死亡之间的关系进行了文献计量分析。该分析可为铁死亡和肠道微生物群的当前研究现状及未来发展提供新的见解。
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