Liu Siyu, Geng Daoying
Radiology Department, Huashan Hospital, Affiliated with Fudan University, Shanghai, China.
Shanghai Engineering Research Center of Intelligent Imaging for Critical Brain Diseases, Shanghai, China.
Front Aging Neurosci. 2024 May 1;16:1377672. doi: 10.3389/fnagi.2024.1377672. eCollection 2024.
Alzheimer's disease (AD) is a degenerative illness of the central nervous system that is irreversible and is characterized by gradual behavioral impairment and cognitive dysfunction. Researches on exosomes in AD have gradually gained the attention of scholars in recent years. However, the literatures in this research area do not yet have a comprehensive visualization analysis. The aim of this work is to use bibliometrics to identify the knowledge constructs and investigate the research frontiers and hotspots related to exosomes in AD.
From January 2003 until June 2023, we searched the Web of Science Core Collection for literature on exosomes in AD. We found 585 papers total. The bibliometric study was completed using VOSviewer, the R package "bibliometrix," and CiteSpace. The analysis covered nations, institutions, authors, journals, and keywords.
Following 2019, the articles on exosomes in AD increased significantly year by year. The vast majority of publications came from China and the US. The University of California System, the National Institutes of Health, and the NIH National Institute on Aging in the US were the primary research institutions. Goetzl Edward J. was frequently co-cited, while Kapogiannis Dimitrios was the most prolific author in this discipline with the greatest number of articles. Lee Mijung et al. have been prominent in the last two years in exosomes in AD. The Journal of Alzheimer's Disease was the most widely read publication, and Alzheimers & Dementia had the highest impact factor. The Journal of Biological Chemistry, Proceedings of the National Academy of Sciences of the United States of America, and Journal of Alzheimer's Disease were the three journals with more than 1,000 citations. The primary emphasis of this field was Alzheimer's disease, exosomes, and extracellular vesicles; since 2017, the number of phrases pertaining to the role of exosomes in AD pathogenesis has increased annually. "Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study" was the reference with the greatest citing power, indicating the future steered direction in this field.
Using bibliometrics, we have compiled the research progress and tendencies on exosomes in Alzheimer's disease for the first time. This helps determine the objectives and paths for future study.
阿尔茨海默病（AD）是一种中枢神经系统退行性疾病，不可逆转，其特征为行为逐渐受损和认知功能障碍。近年来，关于AD中外泌体的研究逐渐受到学者们的关注。然而，该研究领域的文献尚未有全面的可视化分析。本研究的目的是利用文献计量学来识别知识结构，并探究与AD中外泌体相关的研究前沿和热点。
从2003年1月至2023年6月，我们在科学网核心合集（Web of Science Core Collection）中检索关于AD中外泌体的文献。我们共找到585篇论文。使用VOSviewer、R包“bibliometrix”和CiteSpace完成文献计量学研究。分析涵盖国家、机构、作者、期刊和关键词。
2019年之后，关于AD中外泌体的文章逐年显著增加。绝大多数出版物来自中国和美国。美国的加利福尼亚大学系统、国立卫生研究院以及国立卫生研究院国家衰老研究所是主要研究机构。戈茨尔·爱德华·J.被频繁共引，而卡波吉安尼斯·迪米特里奥斯是该领域发文量最多、文章数量最多的作者。李美静等人在过去两年中在AD中外泌体研究方面表现突出。《阿尔茨海默病杂志》是阅读量最广的出版物，《阿尔茨海默病与痴呆》的影响因子最高。《生物化学杂志》《美国国家科学院院刊》和《阿尔茨海默病杂志》是被引次数超过1000次的三本期刊。该领域主要关注阿尔茨海默病、外泌体和细胞外囊泡；自2017年以来，与外泌体在AD发病机制中的作用相关的短语数量逐年增加。“通过神经源性血液外泌体中致病蛋白谱鉴定临床前阿尔茨海默病：一项病例对照研究”是被引影响力最大的参考文献，表明了该领域未来的导向方向。
我们首次利用文献计量学梳理了阿尔茨海默病中外泌体的研究进展和趋势。这有助于确定未来研究的目标和路径。
