2018 年 8 月至 9 月，乌干达西南部卡姆文盖区布西利巴县淋巴丝虫病的血清抗原流行情况和疣状足的危险因素。
Sero-antigen prevalence of lymphatic filariasis and risk factors of podoconiosis in Busiriba sub-county, Kamwenge district, Southwestern Uganda, August-September 2018.
机构信息
Department of Medical Laboratory Sciences Faculty of Medicine, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Department of Medical Laboratory Sciences, Faculty of Health Sciences, Muni University, P.O Box 725, Arua, Uganda.
出版信息
BMC Res Notes. 2024 May 17;17(1):141. doi: 10.1186/s13104-024-06801-z.
OBJECTIVE
Given the neglected nature of filariasis, especially in Uganda where data are scarce, this cross-sectional study aimed to determine the sero-antigen prevalence of lymphatic filariasis and risk factors associated with non-lymphatic filariasis (podoconiosis) in Busiriba Sub-county, Kamwenge District, Uganda, during August-September 2018, to inform targeted elimination efforts.
RESULTS
We enrolled 101 participants, among whom 35 (34.7%) had podoconiosis. The sero-antigen prevalence of lymphatic filariasis was 1.0%. Older age and walking barefoot were associated with increased podoconiosis risk. Specifically, individuals aged 25-49 years with had 7.38 times higher odds of podoconiosis (adjusted odds ratio [aOR] = 7.38, 95% CI: 1.36-40.13) compared to those under 25 years, while those aged ≥ 50 years had even higher odds (aOR = 8.49, 95%CI: 1.44-50.15). Additionally, individuals who reported walking barefoot had 14 times higher odds of podoconiosis (aOR = 14.08; 95% CI: 2.49-79.50).
目的
鉴于盘尾丝虫病（尤其是在乌干达，数据匮乏）被忽视的情况，本横断面研究旨在确定淋巴丝虫病的血清抗原流行率以及与乌干达卡姆文盖区布西利巴县非淋巴丝虫病（疣状足）相关的风险因素，以为有针对性的消除工作提供信息。
结果
我们招募了 101 名参与者，其中 35 名（34.7%）患有疣状足。淋巴丝虫病的血清抗原流行率为 1.0%。年龄较大和赤脚行走与疣状足风险增加有关。具体而言，25-49 岁的个体比 25 岁以下的个体患疣状足的几率高 7.38 倍（调整后的优势比[aOR]=7.38，95%CI：1.36-40.13），而 50 岁及以上的个体的患病几率更高（aOR=8.49，95%CI：1.44-50.15）。此外，报告赤脚行走的个体患疣状足的几率高 14 倍（aOR=14.08；95%CI：2.49-79.50）。
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