Xu Rebecca Z, Guo Ru C, Wijesinghe Printha, Joshua Temitope G, Ayub Aysha, Lee Melissa, Nunez Desmond A
Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
J Laryngol Otol. 2024 Nov;138(11):1090-1094. doi: 10.1017/S0022215124000781. Epub 2024 May 20.
While the pathogenesis of sudden sensorineural hearing loss is thought to be localised to the cochlea, recent microRNA findings suggest a neuro-topic localisation in some patients. This study distinguishes if neural and non-neural groups differ in hearing recovery.
Neural-type hearing loss was defined as a presenting word recognition score less than 60 per cent, with a word recognition score reduction greater than 20 per cent than expected based on the averaged pure tone audiometry. Hearing recovery was defined as an improvement of greater than or equal to 10 decibels in pure tone audiometric thresholds.
Eight of 12 and 24 of 36 of neural and non-neural hearing loss patients demonstrated hearing recovery, respectively. The affected ear's word recognition score (per cent) change with treatment were different between the neural and non-neural groups (46.9 ± 29.8 3.2 ± 25.8 ( < 0.0001)).
The hearing recovery rate in neural and non-neural hearing loss groups was similar. Patients with neural-type hearing loss demonstrated greater word recognition score recovery post treatment than those in the sensory group.
虽然突发性感音神经性听力损失的发病机制被认为局限于耳蜗,但最近的微小RNA研究结果表明,在一些患者中存在神经源性定位。本研究旨在区分神经型和非神经型听力损失患者在听力恢复方面是否存在差异。
神经型听力损失定义为初始单词识别得分低于60%,且单词识别得分降低幅度比基于平均纯音听力测定预期的降幅大20%以上。听力恢复定义为纯音听力阈值改善大于或等于10分贝。
神经型和非神经型听力损失患者中分别有12例中的8例和36例中的24例表现出听力恢复。治疗后,神经型和非神经型组患耳的单词识别得分(百分比)变化不同(46.9±29.8对3.2±25.8,P<0.0001)。
神经型和非神经型听力损失组的听力恢复率相似。神经型听力损失患者治疗后的单词识别得分恢复程度高于感觉型组患者。