新型冠状病毒肺炎遗传易感性的研究进展。

Progresses on genetic susceptibility of COVID-19.

机构信息

State Key Laboratory of Proteomics, National Center for Protein Sciences at Beijing, Beijing Institute of Radiation Medicine, Beijing 100850, China.

College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China.

出版信息

Yi Chuan. 2023 Nov 20;45(11):963-975. doi: 10.16288/j.yczz.23-215.

DOI:10.16288/j.yczz.23-215

PMID:38764262

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). Genetic factors might influence susceptibility to the SARS-CoV-2 infection or disease severity. Genome-wide association studies (GWASs) have identified multiple susceptible genes related to COVID-19 phenotypes, providing the scientific basis for the COVID-19 prevention and treatment. In this review, we summarize the recent progresses of COVID-19 susceptible genes, including the GWASs on multiple phenotypes of COVID-19, GWASs of COVID-19 in multiple ethnic populations, GWASs of COVID-19 based on multiple types of genetic variations, and the fine-mapping of the regions surrounding the susceptible genes.

摘要

严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染引起广泛的 2019 年冠状病毒病（COVID-19）临床谱。遗传因素可能影响对 SARS-CoV-2 感染或疾病严重程度的易感性。全基因组关联研究（GWAS）已经确定了多个与 COVID-19 表型相关的易感基因，为 COVID-19 的预防和治疗提供了科学依据。在这篇综述中，我们总结了 COVID-19 易感基因的最新进展，包括对 COVID-19 多种表型的 GWAS、对多个种族人群 COVID-19 的 GWAS、基于多种类型遗传变异的 COVID-19 的 GWAS 以及易感基因周围区域的精细映射。