他莫昔芬作为双相情感障碍潜在治疗方法的应用。
The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder.
作者信息
Bagdadi Noy, N Azab Abed, Shvartsur Rachel
机构信息
Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Israel.
Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Israel.
出版信息
Psychiatry Clin Psychopharmacol. 2021 Sep 1;31(3):344-352. doi: 10.5152/pcp.2021.21817. eCollection 2021 Sep.
Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient's quality of life and causes significant morbidity and mortality. Although there are a variety of available treatments, therapeutic intervention is not beneficial in many cases and recurrence rates remain high. Recent data suggested tamoxifen, a drug with a wide range of activities, as a potential treatment for reducing manic symptoms of BD. Tamoxifen's therapeutic effect on bipolar mania has not been fully elucidated, but it is believed to biochemically operate on protein kinase C (PKC) inhibition. In this article, we review preclinical and clinical studies investigating the efficacy of tamoxifen as a potential treatment for bipolar manic patients.
双相情感障碍（BD）是一种慢性精神疾病，严重影响患者的生活质量，并导致显著的发病率和死亡率。尽管有多种可用的治疗方法，但在许多情况下治疗干预并无益处，复发率仍然很高。最近的数据表明，他莫昔芬这种具有广泛活性的药物，可能是一种减轻双相情感障碍躁狂症状的潜在治疗方法。他莫昔芬对双相躁狂症的治疗作用尚未完全阐明，但据信它在生物化学上是通过抑制蛋白激酶C（PKC）起作用的。在本文中，我们综述了研究他莫昔芬作为双相躁狂症患者潜在治疗方法疗效的临床前和临床研究。
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