Wei Linping, Laukkanen Jari A, Li Yufeng, Chen Xinrui, Li Gang
Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, 70211, Finland.
Int J Gen Med. 2024 May 15;17:2151-2161. doi: 10.2147/IJGM.S465053. eCollection 2024.
Previous studies have confirmed that high apolipoprotein B/apolipoprotein A1 (apoB/apoA1) ratio was associated with increased mortality from heart failure (HF). Furthermore, the association of plasma apoB/apoA1 ratio with clinical characteristics and adverse cardiac remodeling is still limited in chronic HF with mildly reduced ejection fraction (HFmrEF) elderly patients. Therefore, this study investigated the association of apoB/apoA1 ratio with clinical characteristics and adverse cardiac remodeling in chronic HFmrEF elderly patients.
A total of 587 Chinese elderly (≥65 years) with coronary heart disease (CHD), HFmrEF (EF 40-50%) and related blood biochemical data were collected retrospectively. The cross-sectional data of echocardiographic and blood parameters were compared between binary apoB/apoA1 groups.
In the elderly CHD patients with chronic HFmrEF, the univariate correlation analysis showed that apoB/apoA1 was correlated with younger age, increased prevalence of type 2 diabetes, erythrocytes, platelet/lymphocyte ratio (PLR), D-dimer, fibrinogen, high sensitivity C-reactive protein and uric acid, and adverse cardiac remodeling (All < 0.05). However, multivariate logistic binary regression analysis found that high apoB/apoA1 ratio (≥0.62) was independently correlated with younger age, increased erythrocytes, PLR, D-dimer and uric acid, and adverse cardiac remodeling (All < 0.05).
In this retrospective study, the high apoB/apoA1 ratio is found to be associated with younger age, increased erythrocytes, PLR, D-dimer and uric acid, and adverse cardiac remodeling in Chinese CHD elderly with chronic HFmrEF.
既往研究证实，载脂蛋白B/载脂蛋白A1（apoB/apoA1）比值升高与心力衰竭（HF）死亡率增加相关。此外，在射血分数轻度降低的慢性心力衰竭（HFmrEF）老年患者中，血浆apoB/apoA1比值与临床特征及不良心脏重塑之间的关联仍较为有限。因此，本研究探讨了慢性HFmrEF老年患者中apoB/apoA1比值与临床特征及不良心脏重塑的关联。
回顾性收集了587例年龄≥65岁的中国冠心病（CHD）、HFmrEF（射血分数40%-50%）患者及相关血液生化数据。比较了apoB/apoA1二分法分组之间的超声心动图和血液参数的横断面数据。
在患有慢性HFmrEF的老年CHD患者中，单因素相关性分析显示，apoB/apoA1与年龄较轻、2型糖尿病患病率增加、红细胞、血小板/淋巴细胞比值（PLR）、D-二聚体、纤维蛋白原、高敏C反应蛋白和尿酸升高以及不良心脏重塑相关（均P<0.05）。然而，多因素logistic二元回归分析发现，高apoB/apoA1比值（≥0.62）与年龄较轻、红细胞、PLR、D-二聚体和尿酸升高以及不良心脏重塑独立相关（均P<0.05）。
在这项回顾性研究中，发现高apoB/apoA1比值与中国患有慢性HFmrEF的老年CHD患者年龄较轻、红细胞、PLR、D-二聚体和尿酸升高以及不良心脏重塑相关。
