毒扁豆碱对遗传性共济失调中视觉 - 前庭相互作用的影响。
The influence of physostigmine on visual-vestibular interaction in hereditary ataxias.
作者信息
Tijssen C C, Endtz L J, Goor C
出版信息
J Neurol Neurosurg Psychiatry. 1985 Oct;48(10):977-81. doi: 10.1136/jnnp.48.10.977.
Abstract
Visual suppression of caloric nystagmus was studied in five patients with hereditary ataxia before and after administration of physostigmine. All patients had an initial abnormal ocular fixation index that improved after physostigmine was given. The data indicate that there is a partly reversible disturbance of visual-vestibular interaction in patients with hereditary ataxia, caused by an impairment of a central cholinergic mechanism.
摘要
在五名遗传性共济失调患者中，研究了毛果芸香碱给药前后冷热性眼震的视觉抑制情况。所有患者最初的眼注视指数均异常，给予毛果芸香碱后有所改善。数据表明，遗传性共济失调患者存在视觉 - 前庭相互作用的部分可逆性障碍，这是由中枢胆碱能机制受损所致。
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