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超高剂量率扫描碳离子束专用剂量监测仪的研制与特性分析

Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams.

作者信息

Yagi Masashi, Shimizu Shinichi, Hamatani Noriaki, Miyoshi Takuto, Nomura Takuya, Toyoda Takashi, Nakatani Mahoro, Tsubouchi Toshiro, Shimizu Masaki, Kuwana Yoshiaki, Umezawa Masumi, Takashina Masaaki, Nishio Teiji, Koizumi Masahiko, Ogawa Kazuhiko, Kanai Tatsuaki

机构信息

Department of Carbon Ion Radiotherapy, Osaka University Graduate School of Medicine, Osaka, Japan.

Department of Medical Physics, Osaka Heavy Ion Therapy Center, Osaka, Japan.

出版信息

Sci Rep. 2024 May 21;14(1):11574. doi: 10.1038/s41598-024-62148-2.

Abstract

The current monochromatic beam mode (i.e., uHDR irradiation mode) of the scanned carbon-ion beam lacks a dedicated dose monitor, making the beam control challenging. We developed and characterized a dedicated dose monitor for uHDR-scanned carbon-ion beams. Furthermore, a simple measurable dose rate (dose rate per spot (DR)) was suggested by using the developed dose monitor and experimentally validating quantities relevant to the uHDR scanned carbon-ion beam. A large plane-parallel ionization chamber (IC) with a smaller electrode spacing was used to reduce uHDR recombination effects, and a dedicated operational amplifier was manufactured for the uHDR-scanned carbon-ion beam. The dose linearity of the IC was within ± 1% in the range of 1.8-12.3 Gy. The spatial inhomogeneity of the dose response of the IC was ± 0.38% inside the ± 40-mm detector area, and a systematic deviation of approximately 2% was measured at the edge of the detector. uHDR irradiation with beam scanning was tested and verified for different doses at the corresponding dose rates (in terms of both the average dose rate and DR). We confirmed that the dose monitor can highlight the characteristics (i.e., dose, dose rate, and dose profile) of uHDR-scanned carbon-ion beams at several dose levels in the monochromatic beam mode.

摘要

扫描碳离子束当前的单色束模式(即超高剂量率(uHDR)照射模式)缺乏专用剂量监测器,这使得束流控制具有挑战性。我们开发并表征了一种用于uHDR扫描碳离子束的专用剂量监测器。此外,通过使用所开发的剂量监测器并对与uHDR扫描碳离子束相关的量进行实验验证,提出了一种简单的可测量剂量率(每点剂量率(DR))。使用电极间距较小的大型平行板电离室(IC)来减少uHDR复合效应,并为uHDR扫描碳离子束制造了专用运算放大器。在1.8 - 12.3 Gy范围内,IC的剂量线性在±1%以内。在±40 mm探测器区域内,IC剂量响应的空间不均匀性为±0.38%,在探测器边缘测量到约2%的系统偏差。针对不同剂量在相应剂量率下(包括平均剂量率和DR)对束扫描的uHDR照射进行了测试和验证。我们证实,该剂量监测器能够在单色束模式下的几个剂量水平突出uHDR扫描碳离子束的特性(即剂量、剂量率和剂量分布)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e4/11109334/3ae55025a956/41598_2024_62148_Fig1_HTML.jpg

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