控制氧气输送以促进组织再生。

The Graeme Clark Institute, The University of Melbourne, Parkville, Melbourne, VIC, Australia.

Department of Biomedical Engineering, Faculty of Engineering and Information Technology, The University of Melbourne, Parkville, Melbourne, VIC, Australia.

Nat Commun. 2024 May 22;15(1):4361. doi: 10.1038/s41467-024-48719-x.

Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become a reality, these systems must consider physiological processes, oxygen release mechanisms and the target application. In this review, we explore the biological relevance of oxygen at both a cellular and tissue level, and the importance of its controlled delivery via engineered biomaterials and devices. Recent advances and upcoming trends in the field are also discussed with a focus on tissue-engineered constructs that could meet metabolic demands to facilitate regeneration.

氧气在人类胚胎发生、内稳态和组织再生中起着至关重要的作用。新兴的工程再生解决方案需要新型的氧气输送系统。为了成为现实，这些系统必须考虑生理过程、氧气释放机制和目标应用。在这篇综述中，我们探讨了氧气在细胞和组织水平上的生物学相关性，以及通过工程生物材料和设备控制其输送的重要性。还讨论了该领域的最新进展和未来趋势，重点是能够满足代谢需求以促进再生的组织工程构建体。