Department of Medical Research Centre, Liaquat University of Health Sciences, Jamshoro, Pakistan.
Department of Molecular Biology and Genetics Laboratory, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.
J Pak Med Assoc. 2024 May;74(5):930-933. doi: 10.47391/JPMA.10284.
TTo investigate the level of interleukin-6 in alopecia areata patients.
The exploratory study was conducted from September to December 2021 at the Sindh Institute of Skin Disease, Karachi, and comprised alopecia areata patients regardless of age and gender in group A, while healthy controls matched for age and gender formed group B. Alopecia areata classification and severity were done using the Severity of Alopecia Tool. Serum interleukin-6 was measured using enzyme-linked immune sorbent assay. Data was analysed using R statistical software v4.2.1.
Of the 100 subjects, 50(50%) with mean age 15.52±10.14 years were cases in group A; 26(52%) females with mean age 16.78±10.77 years, and 24(48%) males with mean age 16.44±10.3 years. The remaining 50(50%) were controls in group B. Interleukin-6 concentration was significantly higher in group A (p<0.05). The concentration was not significantly different between the genders (p>0.05). The concentration was the highest in patients aged 11-20 years, followed by 21-30 years, 31-40 years and 1-10 years.
The concentration of circulatory pro-inflammatory interleukin-6 was significantly higher in alopecia areata patients than in the healthy controls.
研究斑秃患者白细胞介素-6 的水平。
这是一项 2021 年 9 月至 12 月在卡拉奇信德皮肤病研究所进行的探索性研究，纳入了无论年龄和性别均为斑秃患者的 A 组，而年龄和性别相匹配的健康对照者为 B 组。使用脱发严重程度工具对斑秃进行分类和严重程度评估。采用酶联免疫吸附试验测定血清白细胞介素-6。使用 R 统计软件 v4.2.1 分析数据。
100 名受试者中，50 名（50%）年龄 15.52±10.14 岁的患者为 A 组；26 名（52%）女性年龄 16.78±10.77 岁，24 名（48%）男性年龄 16.44±10.3 岁。其余 50 名（50%）为 B 组对照者。A 组白细胞介素-6 浓度明显高于 B 组（p<0.05）。性别间浓度无显著差异（p>0.05）。11-20 岁患者的浓度最高，其次是 21-30 岁、31-40 岁和 1-10 岁患者。
斑秃患者循环促炎白细胞介素-6 浓度明显高于健康对照者。
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