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浆果在年龄相关性神经疾病中的治疗潜力。

Therapeutic potential of berries in age-related neurological disorders.

作者信息

Norouzkhani Narges, Afshari Shaghayegh, Sadatmadani Sayedeh-Fatemeh, Mollaqasem Mohammad Mahdi, Mosadeghi Shakila, Ghadri Hani, Fazlizade Safa, Alizadeh Keyvan, Akbari Javar Pouyan, Amiri Hamidreza, Foroughi Elaheh, Ansari Arina, Mousazadeh Kourosh, Davany Bozorgmehr Abdullahzadeh, Akhtari Kohnehshahri Ata, Alizadeh Alaleh, Dadkhah Parisa Alsadat, Poudineh Mohadeseh

机构信息

Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

出版信息

Front Pharmacol. 2024 May 9;15:1348127. doi: 10.3389/fphar.2024.1348127. eCollection 2024.

Abstract

Aging significantly impacts several age-related neurological problems, such as stroke, brain tumors, oxidative stress, neurodegenerative diseases (Alzheimer's, Parkinson's, and dementia), neuroinflammation, and neurotoxicity. Current treatments for these conditions often come with side effects like hallucinations, dyskinesia, nausea, diarrhea, and gastrointestinal distress. Given the widespread availability and cultural acceptance of natural remedies, research is exploring the potential effectiveness of plants in common medicines. The ancient medical system used many botanical drugs and medicinal plants to treat a wide range of diseases, including age-related neurological problems. According to current clinical investigations, berries improve motor and cognitive functions and protect against age-related neurodegenerative diseases. Additionally, berries may influence signaling pathways critical to neurotransmission, cell survival, inflammation regulation, and neuroplasticity. The abundance of phytochemicals in berries is believed to contribute to these potentially neuroprotective effects. This review aimed to explore the potential benefits of berries as a source of natural neuroprotective agents for age-related neurological disorders.

摘要

衰老对多种与年龄相关的神经问题有显著影响,如中风、脑肿瘤、氧化应激、神经退行性疾病(阿尔茨海默病、帕金森病和痴呆症)、神经炎症和神经毒性。目前针对这些病症的治疗方法往往伴有幻觉、运动障碍、恶心、腹泻和胃肠道不适等副作用。鉴于天然药物的广泛可得性和文化接受度,研究正在探索常见药物中植物的潜在功效。古代医学体系使用了许多植物药和药用植物来治疗各种疾病,包括与年龄相关的神经问题。根据目前的临床研究,浆果可改善运动和认知功能,并预防与年龄相关的神经退行性疾病。此外,浆果可能会影响对神经传递、细胞存活、炎症调节和神经可塑性至关重要的信号通路。浆果中丰富的植物化学物质被认为有助于产生这些潜在的神经保护作用。本综述旨在探讨浆果作为天然神经保护剂来源对与年龄相关的神经障碍的潜在益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f37/11112503/414d575a61d7/fphar-15-1348127-g001.jpg

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