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住院康复治疗帕金森病的效果:近期研究的系统评价。

The Effectiveness of Inpatient Rehabilitation in Parkinson's Disease: A Systematic Review of Recent Studies.

机构信息

Department of Neurology, University Medical Center Groningen, University of Groningen, The Netherlands.

出版信息

J Parkinsons Dis. 2024;14(s1):S93-S112. doi: 10.3233/JPD-230271.

Abstract

BACKGROUND

Parkinson's disease (PD) is a progressive disease, which is associated with the loss of activities of daily living independency. Several rehabilitation options have been studied during the last years, to improve mobility and independency.

OBJECTIVE

This systematic review will focus on inpatient multidisciplinary rehabilitation (MR) in people with Parkinson's disease (PwPD), based on recent studies from 2020 onwards.

METHODS

Search strategy in three databases included: multidisciplinary rehabilitation, Parkinson's Disease, inpatient rehabilitation, motor-, functional- and cognitive performance, cost-effectiveness, Quality of Life, and medication changes/Levodopa equivalent daily doses.

RESULTS

Twenty-two studies were included, consisting of 13 studies dealing with inpatient MR and 9 studies on inpatient non-MR interventions. Inpatient PD multidisciplinary rehabilitation proved to be effective, as well as non-MR rehabilitation.

CONCLUSIONS

This review confirms the efficacy of inpatient MR and non-MR in PD, but is skeptical about the past and current study designs. New study designs, including new physical training methods, more attention to medication and costs, new biomarkers, artificial intelligence, and the use of wearables, will hopefully change rehabilitation trials in PwPD in the future.

摘要

背景

帕金森病(PD)是一种进行性疾病,会导致日常生活活动独立性丧失。近年来,已经研究了几种康复选择,以提高运动能力和独立性。

目的

本系统评价将重点关注 2020 年以来基于近期研究的帕金森病患者(PwPD)的住院多学科康复(MR)。

方法

在三个数据库中进行了搜索策略,包括多学科康复、帕金森病、住院康复、运动、功能和认知表现、成本效益、生活质量以及药物变化/左旋多巴等效日剂量。

结果

共纳入 22 项研究,其中 13 项研究涉及住院 MR,9 项研究涉及住院非-MR 干预。住院 PD 多学科康复证明是有效的,非-MR 康复也是有效的。

结论

本综述证实了住院 MR 和非-MR 在 PD 中的疗效,但对过去和当前的研究设计持怀疑态度。新的研究设计,包括新的物理训练方法、更多关注药物和成本、新的生物标志物、人工智能以及可穿戴设备的使用,有望改变未来 PwPD 的康复试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1247/11380234/a72090874428/jpd-14-jpd230271-g001.jpg

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