Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
Int J Mol Sci. 2024 May 9;25(10):5144. doi: 10.3390/ijms25105144.
Non-coding RNAs (ncRNAs) represent a broad family of molecules that regulate gene expression, including microRNAs, long non-coding RNAs and circular RNAs, amongst others. Dysregulated expression of ncRNAs alters gene expression, which is implicated in the pathogenesis of several malignancies and inflammatory diseases. Gastric cancer is the fifth most frequently diagnosed cancer and the fourth most common cause of cancer-related death. Studies have found that altered expression of ncRNAs may contribute to tumourigenesis through regulating proliferation, apoptosis, drug resistance and metastasis. This review describes the potential use of ncRNAs as diagnostic and prognostic biomarkers. Moreover, we discuss the involvement of ncRNAs in the pathogenesis of gastric cancer, including their interactions with the members of major signalling pathways.
非编码 RNA（ncRNAs）是一类广泛存在的分子，能够调控基因表达，包括 microRNAs、长非编码 RNA 和环状 RNA 等。ncRNAs 的表达失调会改变基因表达，这与多种恶性肿瘤和炎症性疾病的发病机制有关。胃癌是第五大常见癌症，也是癌症相关死亡的第四大常见原因。研究发现，ncRNAs 的表达改变可能通过调节增殖、凋亡、耐药性和转移来促进肿瘤发生。本综述描述了 ncRNAs 作为诊断和预后生物标志物的潜在用途。此外，我们还讨论了 ncRNAs 在胃癌发病机制中的作用，包括它们与主要信号通路成员的相互作用。
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