Garlet Allison, Andre-Frei Valerie, Del Bene Nicolas, Cameron Hunter James, Samuga Anita, Rawat Vimal, Ternes Philipp, Leoty-Okombi Sabrina
BASF Corporation, 540 White Plains Road, Tarrytown, NY 10591, USA.
BASF Beauty Care Solutions, 32 Rue Saint Jean de Dieu, 69007 Lyon, France.
Microorganisms. 2024 May 18;12(5):1021. doi: 10.3390/microorganisms12051021.
The change in the skin microbiome as individuals age is only partially known. To provide a better understanding of the impact of aging, whole-genome sequencing analysis was performed on facial skin swabs of 100 healthy female Caucasian volunteers grouped by age and wrinkle grade. Volunteers' metadata were collected through questionnaires and non-invasive biophysical measurements. A simple model and a biological statistical model were used to show the difference in skin microbiota composition between the two age groups. Taxonomic and non-metric multidimensional scaling analysis showed that the skin microbiome was more diverse in the older group (≥55 yo). There was also a significant decrease in Actinobacteria, namely in , and an increase in . Some and species belonging to the Firmicutes phylum and species belonging to the Proteobacteria phylum increased. In the 18-35 yo younger group, the microbiome was characterized by a significantly higher proportion of and , most strikingly, . The functional analysis using GO terms revealed that the young group has a higher significant expression of genes involved in biological and metabolic processes and in innate skin microbiome protection. The better comprehension of age-related impacts observed will later support the investigation of skin microbiome implications in antiaging protection.
随着个体年龄增长，皮肤微生物群的变化仅部分为人所知。为了更好地理解衰老的影响，对100名按年龄和皱纹等级分组的健康白种女性志愿者的面部皮肤拭子进行了全基因组测序分析。志愿者的元数据通过问卷调查和非侵入性生物物理测量收集。使用简单模型和生物统计模型来显示两个年龄组之间皮肤微生物群组成的差异。分类学和非度量多维尺度分析表明，老年组（≥55岁）的皮肤微生物群更加多样化。放线菌也显著减少，即 ，而 增加。一些属于厚壁菌门的 和 物种以及属于变形菌门的物种增加。在18 - 35岁的年轻组中，微生物群的特征是 和 的比例显著更高，最明显的是 。使用GO术语进行的功能分析表明，年轻组中参与生物和代谢过程以及皮肤微生物群先天保护的基因有更高的显著表达。对观察到的与年龄相关影响的更好理解，将有助于日后对皮肤微生物群在抗衰老保护中的意义进行研究。
