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鸭坦布苏病毒感染研究进展。

Advancements in Research on Duck Tembusu Virus Infections.

机构信息

Engineering Technology Research Center for Modern Animal Science and Novel Veterinary Pharmaceutic Development, Jiangsu Key Laboratory of Veterinary Bio-Pharmaceutical High Technology Research, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China.

Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hubei University of Medicine, Shiyan 442000, China.

出版信息

Viruses. 2024 May 20;16(5):811. doi: 10.3390/v16050811.

Abstract

Duck Tembusu Virus (DTMUV) is a pathogen of the Flaviviridae family that causes infections in poultry, leading to significant economic losses in the duck farming industry in recent years. Ducks infected with this virus exhibit clinical symptoms such as decreased egg production and neurological disorders, along with serious consequences such as ovarian hemorrhage, organ enlargement, and necrosis. Variations in morbidity and mortality rates exist across different age groups of ducks. It is worth noting that DTMUV is not limited to ducks alone; it can also spread to other poultry such as chickens and geese, and antibodies related to DTMUV have even been found in duck farm workers, suggesting a potential risk of zoonotic transmission. This article provides a detailed overview of DTMUV research, delving into its genomic characteristics, vaccines, and the interplay with host immune responses. These in-depth research findings contribute to a more comprehensive understanding of the virus's transmission mechanism and pathogenic process, offering crucial scientific support for epidemic prevention and control.

摘要

鸭坦布苏病毒(DTMUV)是黄病毒科的病原体,可引起家禽感染,近年来给养鸭业造成了重大经济损失。感染该病毒的鸭子会出现产蛋量下降和神经紊乱等临床症状,还会导致卵巢出血、器官肿大和坏死等严重后果。不同年龄组的鸭子发病率和死亡率存在差异。值得注意的是,DTMUV 不仅限于鸭子,还可以传播到其他家禽如鸡和鹅,而且在鸭场工人中也发现了与 DTMUV 相关的抗体,这表明存在人畜共患传播的潜在风险。本文详细介绍了 DTMUV 的研究情况,深入探讨了其基因组特征、疫苗以及与宿主免疫反应的相互作用。这些深入的研究结果有助于更全面地了解病毒的传播机制和致病过程,为疫情防控提供了重要的科学支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d72d/11126125/56bb13489245/viruses-16-00811-g001.jpg

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