Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, 10000 Zagreb, Croatia.
Pharmacy Unit, Children's Hospital Zagreb, 10000 Zagreb, Croatia.
Nutrients. 2024 May 12;16(10):1456. doi: 10.3390/nu16101456.
Although parenteral nutrition (PN) significantly improves mortality rates in pediatric short bowel syndrome (SBS), long-term PN has many possible complications and impacts quality of life. Bowel lengthening procedures (BLPs) increase the contact surface of food and the intestinal mucosa and enable the better absorption of nutrients and liquids, possibly leading to a PN decrease.
We retrospectively reviewed the data of patients with short bowel syndrome who underwent BLPs in the period from January 2016 to January 2022. Overall, eight patients, four male, five born prematurely, underwent BLPs.
There was a significant decrease in the percentage of total caloric intake provided via PN and PN volume after the BLPs. The more evident results were seen 6 months after the procedure and at the last follow-up, which was, on average, 31 months after the procedure. Two patients were weaned off PN after their BLPs. Patients remained well nourished during the follow-up.
The BLP led to a significant decrease in PN needs and an increase in the food intake; however, significant changes happened more than 6 months after the procedure.
尽管肠外营养（PN）显著提高了儿科短肠综合征（SBS）的死亡率，但长期 PN 有许多可能的并发症，并影响生活质量。肠延长术（BLPs）增加了食物和肠黏膜的接触面积，使营养和液体更好地吸收，可能导致 PN 减少。
我们回顾性分析了 2016 年 1 月至 2022 年 1 月期间接受 BLPs 的短肠综合征患者的数据。共有 8 名患者，4 名男性，5 名早产儿，接受了 BLPs。
BLPs 后，PN 提供的总热量摄入百分比和 PN 量显著减少。该结果在术后 6 个月和最后一次随访时更为明显，平均为术后 31 个月。2 例患者在 BLPs 后停用 PN。患者在随访期间营养状况良好。
BLP 导致 PN 需求显著减少，食物摄入量增加；然而，显著变化发生在术后 6 个月后。
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