College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Nephrology, Shulan (Hangzhou) Hospital, Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang, China.
Front Immunol. 2024 May 10;15:1382977. doi: 10.3389/fimmu.2024.1382977. eCollection 2024.
CD38 antigen is a glycoprotein that found on the surface of several immune cells, and this property makes its monoclonal antibodies have the effect of targeted elimination of immune cells. Therefore, the CD38 monoclonal antibody (such as daratumumab, Isatuximab) becomes a new treatment option for membranous nephropathy, lupus nephritis, renal transplantation, and other refractory kidney diseases. This review summarizes the application of CD38 monoclonal antibodies in different kidney diseases and highlights future prospects.
CD38 抗原是一种糖蛋白，存在于几种免疫细胞的表面，这一特性使其单克隆抗体具有靶向清除免疫细胞的作用。因此，CD38 单克隆抗体（如达雷妥尤单抗、伊沙妥昔单抗）成为膜性肾病、狼疮性肾炎、肾移植和其他难治性肾脏疾病的新治疗选择。本综述总结了 CD38 单克隆抗体在不同肾脏疾病中的应用，并展望了未来前景。
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