Ali Maqsood, Kim Yong-Sik
Department of Microbiology, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of Korea.
Department of Microbiology, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of Korea; Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan, Chungnam 31151, Republic of Korea.
J Adv Res. 2025 May;71:337-354. doi: 10.1016/j.jare.2024.05.024. Epub 2024 May 27.
The prevalence of osteoporosis (OP) on a global scale is significantly elevated that causes life threatening issues. The potential of groundbreaking biomolecular therapeutics in the field of OP is highly encouraging. The administration of biomolecular agents has the potential to mitigate the process of bone demineralization while concurrently augmenting the regenerative capacity of bone tissue, thereby facilitating a personalized therapeutic approach. Biomolecules-based therapies showed promising results in term of bone mass protection and restoration in OP.
We summarized the recent biomolecular therapies with notable progress in clinical, demonstrating the potential to transform illness management. These treatments frequently utilize different biomolecule based strategies. Biomolecular therapeutics has a targeted character, which results in heightened specificity and less off-target effects, ultimately leading to increased patient outcomes. These aspects have the capacity to greatly enhance the management of OP, thus resulting in a major enhancement in the quality of life encountered by individuals affected by this condition.
全球范围内骨质疏松症(OP)的患病率显著升高,引发了危及生命的问题。OP领域开创性生物分子疗法的潜力非常令人鼓舞。生物分子药物的施用有可能减轻骨脱矿过程,同时增强骨组织的再生能力,从而促进个性化治疗方法。基于生物分子的疗法在OP的骨量保护和恢复方面显示出有前景的结果。
我们总结了近期在临床方面取得显著进展的生物分子疗法,展示了改变疾病管理的潜力。这些治疗通常采用不同的基于生物分子的策略。生物分子疗法具有靶向性,这导致更高的特异性和更少的脱靶效应,最终提高患者的治疗效果。这些方面有能力极大地改善OP的管理,从而使受该疾病影响的个体的生活质量得到重大提高。