Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, College of the Environment and Ecology, Xiamen University, Xiamen, Fujian, China.
Biomedical Sciences, College of Dental Medicine, Western University of Health Sciences, Pomona, CA, USA.
Nat Commun. 2024 May 30;15(1):4615. doi: 10.1038/s41467-024-49024-3.
Parental or ancestral environments can induce heritable phenotypic changes, but whether such environment-induced heritable changes are a common phenomenon remains unexplored. Here, we subject 14 genotypes of Arabidopsis thaliana to 10 different environmental treatments and observe phenotypic and genome-wide gene expression changes over four successive generations. We find that all treatments caused heritable phenotypic and gene expression changes, with a substantial proportion stably transmitted over all observed generations. Intriguingly, the susceptibility of a genotype to environmental inductions could be predicted based on the transposon abundance in the genome. Our study thus challenges the classic view that the environment only participates in the selection of heritable variation and suggests that the environment can play a significant role in generating of heritable variations.
父母或祖先的环境可以诱导可遗传的表型变化，但这种环境诱导的可遗传变化是否是一种普遍现象仍未被探索。在这里，我们对 14 种拟南芥基因型进行了 10 种不同的环境处理，并观察了在连续四代中的表型和全基因组基因表达变化。我们发现，所有处理都导致了可遗传的表型和基因表达变化，其中相当大的一部分在所有观察到的世代中稳定传递。有趣的是，一个基因型对环境诱导的敏感性可以根据基因组中转座子的丰度来预测。因此，我们的研究挑战了经典的观点，即环境仅参与可遗传变异的选择，并表明环境可以在产生可遗传变异方面发挥重要作用。
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