中国深圳意义未明单克隆丙种球蛋白血症的流行率。

Prevalence of monoclonal gammopathy of undetermined significance in Shenzhen, China.

机构信息

Department of Laboratory Medicine, Peking University Shenzhen Hospital, Shenzhen, People's Republic of China.

Department of Laboratory Medicine, Guangzhou Medical University, Guangzhou, People's Republic of China.

出版信息

Hematology. 2024 Dec;29(1):2352686. doi: 10.1080/16078454.2024.2352686. Epub 2024 May 31.

DOI:10.1080/16078454.2024.2352686

PMID:38819332

Abstract

BACKGROUND

Data on the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in China are very limited. Our aim was to determine the prevalence and clinical characteristics of MGUS in a large Chinese population.

METHODS

This study included 49,220 healthy people who received serum immunofixation electrophoresis (sIFE) and serum protein electrophoresis (SPE) tests. Serum free light chain ratio, immunoglobulin quantification, and other clinically correlates of MGUS were performed for all patients with M-protein.

RESULTS

A total of 576 MGUS patients were identified by sIFE, with a median age of 58 years and an overall prevalence of 1.17% (95% CI, 1.08-1.27). Among those aged 50 years and older, the prevalence of MGUS was 2.26% (95% CI, 2.04-2.50). The prevalence of MGUS was significantly higher in males than in females ( < 0.05). The median concentration of M-protein was 3.1 g/L, ranging from 0.5 g/L to 25.1 g/L. The M-protein type was IgG in 55.4% of MGUS patients, followed by IgA (31.1%), IgM (9.5%), IgD (0.5%), biclonal (2.3%), and light chain (1.2%). Abnormalities in SPE, FLC ratios, and immunoglobulin levels were observed in 78.3%, 31.1%, and 38.4% of MGUS patients, respectively.

CONCLUSIONS

The prevalence of MGUS is substantially lower in southern China than in whites and blacks.

摘要

背景

中国关于意义未明的单克隆丙种球蛋白病（MGUS）的流行数据非常有限。我们的目的是确定中国庞大人群中 MGUS 的患病率和临床特征。

方法

这项研究纳入了 49220 名接受血清免疫固定电泳（sIFE）和血清蛋白电泳（SPE）检测的健康人。对所有存在 M 蛋白的患者进行血清游离轻链比、免疫球蛋白定量等与 MGUS 相关的临床检查。

结果

通过 sIFE 共检出 576 例 MGUS 患者，中位年龄为 58 岁，总患病率为 1.17%（95%CI，1.08-1.27）。在 50 岁及以上人群中，MGUS 的患病率为 2.26%（95%CI，2.04-2.50）。MGUS 的患病率在男性中显著高于女性（<0.05）。M 蛋白浓度的中位数为 3.1g/L，范围为 0.5-25.1g/L。在 MGUS 患者中，M 蛋白类型以 IgG 最多（55.4%），其次为 IgA（31.1%）、IgM（9.5%）、IgD（0.5%）、双克隆（2.3%）和轻链（1.2%）。分别有 78.3%、31.1%和 38.4%的 MGUS 患者出现 SPE 异常、FLC 比值异常和免疫球蛋白水平异常。