Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Division of Cardiothoracic Surgery, Department of Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Nat Commun. 2024 Jun 3;15(1):4720. doi: 10.1038/s41467-024-48980-0.
Bioadhesive materials and patches are promising alternatives to surgical sutures and staples. However, many existing bioadhesives do not meet the functional requirements of current surgical procedures and interventions. Here, we present a translational patch material that exhibits instant adhesion to tissues (2.5-fold stronger than Tisseel, an FDA-approved fibrin glue), ultra-stretchability (stretching to >300% its original length without losing elasticity), compatibility with rapid photo-projection (<2 min fabrication time/patch), and ability to deliver therapeutics. Using our established procedures for the in silico design and optimization of anisotropic-auxetic patches, we created next-generation patches for instant attachment to tissues while conforming to a broad range of organ mechanics ex vivo and in vivo. Patches coated with extracellular vesicles derived from mesenchymal stem cells demonstrate robust wound healing capability in vivo without inducing a foreign body response and without the need for patch removal that can cause pain and bleeding. We further demonstrate a single material-based, void-filling auxetic patch designed for the treatment of lung puncture wounds.
生物黏附材料和贴片是手术缝线和订书钉的有前途的替代品。然而，许多现有的生物黏合剂不符合当前手术程序和干预的功能要求。在这里，我们提出了一种转化贴片材料，它具有瞬间黏附组织的能力（比已获得 FDA 批准的纤维蛋白胶 Tisseel 强 2.5 倍）、超拉伸性（拉伸至原始长度的 300%以上而不会失去弹性）、与快速光投影的兼容性（<2 分钟的制造时间/贴片），以及能够输送治疗药物的能力。使用我们为各向异性弹性贴片的计算机模拟设计和优化而建立的程序，我们为下一代贴片的即时组织附着创造了条件，同时适应了广泛的器官力学，包括离体和体内。涂有间充质干细胞衍生的细胞外囊泡的贴片在体内表现出强大的伤口愈合能力，而不会引起异物反应，也不需要去除贴片，这可能会引起疼痛和出血。我们进一步展示了一种基于单一材料的、用于治疗肺穿刺伤口的空洞填充弹性贴片。
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