World Health Organization, Regional Office for the Eastern Mediterranean, Cairo, Egypt.
Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Geneva, Switzerland.
Reprod Health. 2024 Jun 4;20(Suppl 1):192. doi: 10.1186/s12978-024-01805-1.
Despite their importance in reducing maternal mortality, information on access to Mifepristone, Misoprostol, and contraceptive medicines in the Eastern Mediterranean Region is limited.
A standardized assessment tool measuring access to Mifepristone, Misoprostol, and contraceptive medicines included in the WHO essential medicines list (EML) was implemented in eight countries in the Eastern Mediterranean Region (Afghanistan, Iraq, Lebanon, Libya, Morocco, Palestine, Pakistan, and Somalia) between 2020-2021. The assessment focused on five access measures: 1) the inclusion of medicines in national family planning guidelines; 2) inclusion of medicines in comprehensive abortion care guidelines; 3) inclusion of medicines on national essential medicines lists; 4) medicines registration; and 5) procurement and forecasting of Mifepristone, Misoprostol, and contraceptive medicines. A descriptive analysis of findings from these eight national assessments was conducted.
Only Lebanon and Pakistan included all 12 contraceptives that are enlisted in the WHO-EML within their national family planning guidelines. Only Afghanistan and Lebanon included mifepristone and mifepristone-misoprostol combination in post-abortion care guidelines, but these medicines were not included in their national EMLs. Libya and Somalia lacked a national regulatory authority for medicines registration. Most contraceptives included on the national EMLs for Lebanon, Morocco and Pakistan were registered. Misoprostol was included on the EMLs-and registered-in six countries (Afghanistan, Iraq, Lebanon, Morocco, Palestine, and Pakistan). However, only three countries procured misoprostol (Iraq, Morocco, and Somalia).
These findings can guide efforts aimed at improving the availability of Mifepristone, Misoprostol, and contraceptive medicines in the Eastern Mediterranean Region. Opportunities include expanding national EMLs to include more options for Mifepristone, Misoprostol, and contraceptive medicines and strengthening the registration and procurement systems to ensure these medicines' availability were permitted under national law and where culturally acceptable.
尽管米非司酮、米索前列醇和避孕药具在降低孕产妇死亡率方面至关重要,但在东地中海地区,有关这些药物可及性的信息有限。
2020-2021 年期间,在东地中海地区的 8 个国家(阿富汗、伊拉克、黎巴嫩、利比亚、摩洛哥、巴勒斯坦、巴基斯坦和索马里)实施了一项标准化评估工具,以衡量米非司酮、米索前列醇和列入世卫组织基本药物清单(EML)的避孕药具的可及性。该评估侧重于五个获取途径指标:1)药物是否列入国家计划生育指南;2)药物是否列入全面堕胎护理指南;3)药物是否列入国家基本药物清单;4)药物注册;5)米非司酮、米索前列醇和避孕药具的采购和预测。对这 8 个国家评估结果进行了描述性分析。
只有黎巴嫩和巴基斯坦在其国家计划生育指南中列入了世卫组织 EML 中列出的所有 12 种避孕药具。只有阿富汗和黎巴嫩在堕胎后护理指南中列入了米非司酮和米非司酮-米索前列醇联合用药,但这些药物未列入其国家 EML。利比亚和索马里缺乏药品注册的国家管理机构。列入黎巴嫩、摩洛哥和巴基斯坦国家 EML 的大多数避孕药具均已注册。米索前列醇在 6 个国家(阿富汗、伊拉克、黎巴嫩、摩洛哥、巴勒斯坦和巴基斯坦)列入 EML 并已注册。然而,只有 3 个国家采购了米索前列醇(伊拉克、摩洛哥和索马里)。
这些发现可以为改善东地中海地区米非司酮、米索前列醇和避孕药具的可及性提供指导。机会包括扩大国家 EML,纳入更多米非司酮、米索前列醇和避孕药具的选择,并加强注册和采购系统,以确保这些药物在国家法律允许的范围内且在文化上可接受的情况下能够获得。