Baniya Aashish, Koirala Diwakar, Dahal Alok, Khadka Grishma
BP Koirala Institute of Health Sciences, Dharan, Nepal.
Ann Med Surg (Lond). 2024 Apr 24;86(6):3694-3697. doi: 10.1097/MS9.0000000000002089. eCollection 2024 Jun.
Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma characterized by chromosome 8 MYC gene translocation. It manifests in three clinical types: immunodeficiency-related, sporadic (nonendemic), and endemic (African), each differing in epidemiology and clinical behavior. Treatment typically involves enrollment in clinical trials or intensive chemotherapy regimens like R-CODOX-M/IVAC. The authors present a case of recurrent BL following treatment.
A 13-year-old female presented with a gradually progressive swelling in the left parieto-occipital region. Examination revealed normal vital signs and a Glasgow coma scale, with seronegative findings on investigations. An excision of a subganglion soft tissue tumor was performed, revealing histopathological features suggestive of a small round blue cell tumor. After chemotherapy, the patient experienced a recurrence in the scalp region, diagnosed as BL.
While scarce reports exist on BL in the scalp region, cases have been documented in various body locations. Treatment strategies, including chemotherapy and surgery, have shown promising results in managing the disease and improving symptoms.
The recurrence of BL is rare, highlighting the importance of vigilance in monitoring patients post-treatment. The authors report a case of recurrent BL in a 13-year-old female, emphasizing the need for continued research and surveillance in managing this aggressive malignancy.
伯基特淋巴瘤(BL)是一种侵袭性非霍奇金淋巴瘤,其特征为8号染色体上的MYC基因易位。它表现为三种临床类型:免疫缺陷相关型、散发性(非地方性)和地方性(非洲型),每种类型在流行病学和临床行为上都有所不同。治疗通常包括参加临床试验或采用如R-CODOX-M/IVAC等强化化疗方案。作者报告了一例治疗后复发的伯基特淋巴瘤病例。
一名13岁女性因左顶枕部逐渐进行性肿胀就诊。检查显示生命体征和格拉斯哥昏迷量表评分正常,检查结果为血清学阴性。对一个神经节下软组织肿瘤进行了切除,组织病理学特征提示为小圆形蓝细胞瘤。化疗后,患者头皮区域复发,诊断为伯基特淋巴瘤。
虽然关于头皮区域伯基特淋巴瘤的报道很少,但在身体各个部位都有病例记录。包括化疗和手术在内的治疗策略在控制疾病和改善症状方面已显示出有希望的结果。
伯基特淋巴瘤的复发很少见,突出了治疗后对患者进行监测时保持警惕的重要性。作者报告了一例13岁女性复发性伯基特淋巴瘤病例,强调了在管理这种侵袭性恶性肿瘤方面持续研究和监测的必要性。