Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Center for Stroke Research Berlin (CSB), Berlin, Germany.
Commun Biol. 2024 Jun 7;7(1):700. doi: 10.1038/s42003-024-06399-9.
Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic aphasia remain incompletely understood. Using lesion symptom mapping, we demonstrate that lesions in the left ventrolateral and ventral anterior thalamic nucleus are most strongly associated with aphasia in general and with impaired semantic and phonemic fluency and complex comprehension in particular. Lesion network mapping (using a normative connectome based on fMRI data from 1000 healthy individuals) reveals a Thalamic aphasia network encompassing widespread left-hemispheric cerebral connections, with Broca's area showing the strongest associations, followed by the superior and middle frontal gyri, precentral and paracingulate gyri, and globus pallidus. Our results imply the critical involvement of the left ventrolateral and left ventral anterior thalamic nuclei in engaging left frontal cortical areas, especially Broca's area, during language processing.
丘脑性失语症是由局灶性丘脑病变引起的，由于语言网络干扰，导致远程但功能上连接的皮质区域功能障碍。然而，丘脑性失语症的特定局部和网络水平的神经基质仍不完全清楚。使用病变症状映射，我们证明左侧腹外侧和腹前核的病变与一般的失语症以及语义和语音流畅性以及复杂理解能力受损密切相关。病变网络映射（使用基于来自 1000 名健康个体的 fMRI 数据的规范连接组）揭示了一个包括广泛的左半球大脑连接的丘脑性失语症网络，其中 Broca 区显示出最强的关联，其次是额上回和中回、中央前回和旁中央回以及苍白球。我们的结果表明，左侧腹外侧和左侧腹前核在语言处理过程中关键地参与了左侧额叶皮质区域，特别是 Broca 区。
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