Engineering Laboratory of Animal Immunity of Jiangsu Province, College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, China.
Institute of Bioengineering, University of Tartu, Nooruse Street 1, Tartu, Estonia.
Nat Commun. 2024 Jun 8;15(1):4906. doi: 10.1038/s41467-024-49301-1.
Various low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.
已鉴定出多种低密度脂蛋白受体（LPR）为甲病毒的进入因子，并确定了相应的病毒-受体复合物结构。在这里，我们分析了多种甲病毒的受体结合模式的相似性和差异性，以了解它们感染广泛宿主的能力。我们还进一步讨论了针对多种甲病毒开发广谱治疗策略所面临的挑战。
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