Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA.
Med Phys. 2024 Sep;51(9):6378-6389. doi: 10.1002/mp.17231. Epub 2024 Jun 9.
Optically stimulated luminescent dosimeters (OSLDs) can be bleached and reused, but questions remain about the effects of repeated bleaching and fractionation schedules on OSLD performance.
The aim of this study was to investigate how light sources with different wavelengths and different fractionation schemes affect the performance of reused OSLDs.
OSLDs (N = 240) were irradiated on a cobalt-60 beam in different step sizes until they reached an accumulated dose of 50 Gy. Between irradiations they were bleached using light sources of different wavelengths: the Imaging and Radiation Oncology Core (IROC) bleaching system (our control); monochromatic red, green, yellow, and blue lights; and a polychromatic white light. Sensitivity and linearity-based correction factors were determined as a function of dose step-size. The rate of signal removal from different light sources was characterized by sampling these OSLDs at various time points during their bleaching process. Relative doses were calculated according to the American Association of Physicists in Medicine Task Group-191. Signal repopulation was investigated by irradiating OSLDs (N = 300) to various delivered doses of 2, 10, 20, 30, 40, and 50 Gy in a single fraction, bleached with one of the colors, and read over time. Fractionation effects were evaluated by irradiating OSLDs up to 30 Gy in different size steps. After reading, the OSLDs were bleached following IROC protocol. OSLDs (N = 40) received irradiations in 5, 10, 15, 30 Gy fractions until they had an accumulated dose of 30 Gy; The sensitivity response of these OSLDs was compared with reference OSLDs that had no accumulated dose.
Light sources with polychromatic spectrums (IROC and white) bleached OSLDs faster than did sources with monochromatic spectra. Polychromatic light sources (white light and IROC system) provided the greatest dose stability for OSLDs that had larger amounts of accumulated dose. Signal repopulation was related to the choice of bleaching light source, timing of bleaching, and amount of accumulated dose. Changes to relative dosimetry were more pronounced in OSLDs that received larger fractions. At 5-Gy fractions and above, all OSLDs had heightened sensitivity, with OSLDs exposed to 30-Gy fractions being 6.4% more sensitive than reference dosimeters.
The choice of bleaching light plays a role in how fast an OSLD is bleached and how much accumulated dose an OSLD can be exposed to while maintaining stable signal sensitivity. We have expanded upon investigations into signal repopulation to show that bleaching light plays a role in the migration of deep traps to dosimetric traps after bleaching. Our research concludes that the bleaching light source and fractionation need to be considered when reusing OSLD.
光激励发光剂量计(OSLD)可被漂白并重复使用,但关于重复漂白和分割方案对 OSLD 性能的影响仍存在疑问。
本研究旨在探讨不同波长的光源和不同分割方案如何影响重复使用的 OSLD 的性能。
在钴-60 射束中以不同的剂量步长照射 OSLD(N=240),直到它们达到 50 Gy 的累积剂量。在照射之间,使用不同波长的光源进行漂白:成像和放射肿瘤学核心(IROC)漂白系统(我们的对照);单色红光、绿光、黄光和蓝光;以及多色白光。作为剂量步长的函数,确定了灵敏度和基于线性的校正因子。通过在漂白过程的不同时间点对这些 OSLD 进行采样,来描述不同光源去除信号的速率。根据美国医学物理学家协会任务组 191 计算相对剂量。通过以单部分方式照射 OSLD(N=300)至 2、10、20、30、40 和 50 Gy 的不同传递剂量,研究信号再填充,并用一种颜色漂白,并随时间读取。通过在不同大小的步骤中照射 OSLD 至 30 Gy 来评估分割效果。读取后,按照 IROC 方案对 OSLD 进行漂白。在 5、10、15、30 Gy 剂量的分次照射下,40 个 OSLD 累积剂量达到 30 Gy;将这些 OSLD 的灵敏度响应与没有累积剂量的参考 OSLD 进行比较。
多色光谱(IROC 和白光)光源比单色光谱光源更快地漂白 OSLD。对于累积剂量较大的 OSLD,多色光源(白光和 IROC 系统)提供了最大的剂量稳定性。信号再填充与漂白光源的选择、漂白时间和累积剂量有关。在接受较大剂量的 OSLD 中,相对剂量的变化更为明显。在 5 Gy 分次照射以上,所有 OSLD 的灵敏度都有所提高,接受 30 Gy 分次照射的 OSLD 比参考剂量计敏感 6.4%。
漂白光源的选择在 OSLD 被漂白的速度以及 OSLD 在保持信号灵敏度稳定的情况下可以承受的累积剂量方面起着作用。我们已经扩展了对信号再填充的研究,以表明漂白光源在漂白后深陷阱向剂量学陷阱迁移中起作用。我们的研究得出结论,在重复使用 OSLD 时,需要考虑漂白光源和分割。