School of Physical Education, Soochow University, Suzhou, China.
Sports Business School, Beijing Sport University, Beijing, China.
Front Immunol. 2024 May 28;15:1385902. doi: 10.3389/fimmu.2024.1385902. eCollection 2024.
Given the high incidence of sarcopenia among Asians, it is imperative to identify appropriate intervention methods. The International Clinical Practice Guidelines for Sarcopenia, developed by the International Conference on Sarcopenia and Frailty Research (ICFSR) task force, recommends resistance training (RT) as a primary treatment for managing sarcopenia. Inflammatory biomarkers serve as indicators of sarcopenia. However, there is currently insufficient conclusive evidence regarding the effectiveness of RT in modulating inflammatory biomarker levels among Asian participants with sarcopenia.
Four databases were utilized for this study until October 9, 2023. This study focused on randomized controlled trials (RCTs) that examined the effects of RT on interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and interleukin-10 (IL-10) about sarcopenia. This study has been registered in the PROSPERO database (CRD42024501855).
The meta-analysis included six studies from Asians involving 278 participants. The results showed a significant decrease in RT for IL-6 (weighted mean difference (WMD) = -0.73, 95% confidence interval (CI) = -1.02 to -0.44; n=5). However, no significant differences were found for TNF-α (WMD = -1.00, 95% CI = -2.47 to 0.46; n=5), CRP (WMD = -0.45, 95% CI = -1.14 to 0.23; n=3), and IL-10 (WMD = 0.13, 95% CI = -3.99 to 4.25; n=2). Subgroup analysis revealed that factors including gender selection, intervention methods, frequency, period, and duration could have a particular effect on the part of inflammatory biomarkers.
RT has been shown to reduce part of the level of inflammatory markers, specifically IL-6, in Asian sarcopenia participants. However, other inflammatory factors, such as TNF-α, CRP, and IL-10, did not show significant changes. Further research should confirm the impact of RT on these indicators and explore the potential effects of various factors on different inflammatory markers, such as diet, body composition, and medications.
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=501855, identifier CRD42024501855.
鉴于亚洲人群中肌少症的高发率，确定合适的干预方法至关重要。国际肌少症和衰弱研究会议（ICFSR）工作组制定的《国际肌少症临床实践指南》建议将抗阻训练（RT）作为治疗肌少症的主要方法。炎症生物标志物可作为肌少症的指标。然而，目前尚无确凿证据表明 RT 可调节亚洲肌少症参与者的炎症生物标志物水平。
截至 2023 年 10 月 9 日，本研究共使用了 4 个数据库。本研究重点关注了评估 RT 对白细胞介素 6（IL-6）、肿瘤坏死因子-α（TNF-α）、C 反应蛋白（CRP）和白细胞介素 10（IL-10）等炎症生物标志物对肌少症影响的随机对照试验（RCT）。本研究已在 PROSPERO 数据库（CRD42024501855）中注册。
荟萃分析纳入了来自亚洲的 6 项研究，共涉及 278 名参与者。结果显示，RT 可显著降低 IL-6（加权均数差（WMD）=-0.73，95%置信区间（CI）=-1.02 至-0.44；n=5）。然而，TNF-α（WMD=-1.00，95%CI=-2.47 至 0.46；n=5）、CRP（WMD=-0.45，95%CI=-1.14 至 0.23；n=3）和 IL-10（WMD=0.13，95%CI=-3.99 至 4.25；n=2）的差异均无统计学意义。亚组分析显示，性别选择、干预方法、频率、周期和持续时间等因素可能对炎症标志物的部分指标有特殊影响。
RT 可降低亚洲肌少症参与者部分炎症标志物水平，特别是 IL-6。然而，其他炎症因子，如 TNF-α、CRP 和 IL-10，差异无统计学意义。还需要进一步的研究来证实 RT 对这些指标的影响，并探讨不同因素对不同炎症标志物的潜在影响，如饮食、身体成分和药物治疗等。
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=501855，注册号 CRD42024501855。
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