Department of Nutrition and Dietetics, Gülhane Health Sciences Institute, Health Sciences University, Ankara, Turkey.
Specialist of Pediatric Endocrinology, Department of Pediatric Endocrinology, Gülhane Training and Research Hospital, Ankara, Turkey.
BMC Endocr Disord. 2024 Jun 14;24(1):89. doi: 10.1186/s12902-024-01553-0.
The aim was to evaluate the effect of metabolic control on bone biomarkers in children with type I diabetes.
The children were divided into two groups according to their glycated hemoglobin (HbA1c) (%) levels: a group with HbA1c levels < 8% (n = 16) and: a group with HbA1c levels > 8% (n = 18). The serum total oxidative status (TOS) (µmol/L), total antioxidant status (TAS) (mmol/L), alkaline phosphatase (ALP) (IU/L), osteocalcin (OC) (ng/ml), procollagen type-1-N-terminal peptide (P1NP) (ng/ml), and vitamin D (IU) levels and food consumption frequencies were determined.
When patients were classified according to HbA1c (%) levels, those with HbA1c levels < 8% were found to have lower TOS (µmol/L) values (8.7 ± 6.16, 9.5 ± 5.60) and higher serum OC (ng/mL) (24.2 ± 16.92, 22.0 ± 6.21) levels than those with HbA1c levels > 8% (p < 0.05). Regardless of the level of metabolic control, there was a statistically significant association between serum TOS (µmol/L) and P1NP (ng/ml) (p < 0.05) levels, with no group-specific relationship (HbA1c levels <%8 or HbA1c levels >%8).
HbA1c and serum TOS levels had an effect on bone turnover biomarkers in individuals with type I diabetes.
本研究旨在评估代谢控制对 1 型糖尿病儿童骨生物标志物的影响。
根据糖化血红蛋白（HbA1c）水平将儿童分为两组：HbA1c 水平＜8%组（n=16）和 HbA1c 水平＞8%组（n=18）。检测血清总氧化状态（TOS）（µmol/L）、总抗氧化状态（TAS）（mmol/L）、碱性磷酸酶（ALP）（IU/L）、骨钙素（OC）（ng/ml）、I 型前胶原氨基端肽（P1NP）（ng/ml）和维生素 D（IU）水平以及食物摄入频率。
当根据 HbA1c（%）水平对患者进行分类时，HbA1c 水平＜8%组的 TOS（µmol/L）值（8.7±6.16、9.5±5.60）较低，血清 OC（ng/ml）水平（24.2±16.92、22.0±6.21）较高（p＜0.05）。无论代谢控制水平如何，血清 TOS（µmol/L）和 P1NP（ng/ml）之间均存在统计学显著相关性（p＜0.05），与特定组无关（HbA1c 水平＜8%或 HbA1c 水平＞8%）。
HbA1c 和血清 TOS 水平对 1 型糖尿病患者的骨转换生物标志物有影响。
