Mo Yufeng, Li Yamin, Liang Shaoxian, Wang Wuqi, Zhang Honghua, Zhao Jiajia, Xu Mengting, Zhang Xiaoyu, Cao Hongjuan, Xie Shaoyu, Lv Yaning, Wu Yaqin, Zhang Zhuang, Yang Wanshui
Department of Nutrition, Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Anhui, China.
Food Funct. 2024 Jul 15;15(14):7305-7313. doi: 10.1039/d3fo05632e.
: Plant-derived lignans may protect against obesity, while their bioactivity needs gut microbial conversion to enterolignans. We used repeated measures to identify enterolignan-predicting microbial species and investigate whether enterolignans and enterolignan-predicting microbial species are associated with obesity. : Urinary enterolignans, fecal microbiota, body weight, height, and circumferences of the waist (WC) and hips (HC) were repeatedly measured at the baseline and after 1 year in 305 community-dwelling adults in Huoshan, China. Body composition and liver fat [indicated by the controlled attenuation parameter (CAP)] were measured after 1 year. Multivariate-adjusted linear models and linear mixed-effects models were used to analyze single and repeated measurements, respectively. : Enterolactone and enterodiol levels were both inversely associated with the waist-to-hip ratio, body fat mass (BFM), visceral fat level (VFL), and liver fat accumulation (all < 0.05). Enterolactone levels were also associated with lower WC ( = -0.0035 and = 0.013) and HC ( = -0.0028 and = 0.044). We identified multiple bacterial genera whose relative abundance was positively associated with the levels of enterolactone (26 genera) and enterodiol (22 genera, all false discovery rate < 0.05), and constructed the enterolactone-predicting microbial score and enterodiol-predicting microbial score to reflect the overall enterolignan-producing potential of the host gut microbiota. Both these scores were associated with lower body weight and CAP (all < 0.05). The enterolactone-predicting microbial score was also inversely associated with the BFM ( = -0.1128 and = 0.027) and VFL ( = -0.1265 and = 0.044). : Our findings support that modulating the host gut microbiome could be a potential strategy to prevent obesity by enhancing the production of enterolignans.
植物源木脂素可能预防肥胖，但其生物活性需经肠道微生物转化为肠木脂素。我们采用重复测量法来识别预测肠木脂素的微生物种类，并研究肠木脂素和预测肠木脂素的微生物种类是否与肥胖相关。在中国霍山的305名社区居住成年人中，在基线和1年后重复测量尿肠木脂素、粪便微生物群、体重、身高以及腰围（WC）和臀围（HC）。1年后测量身体成分和肝脏脂肪[以受控衰减参数（CAP）表示]。分别使用多变量调整线性模型和线性混合效应模型分析单次和重复测量数据。肠内酯和肠二醇水平均与腰臀比、体脂肪量（BFM）、内脏脂肪水平（VFL）和肝脏脂肪堆积呈负相关（均P<0.05）。肠内酯水平还与较低的腰围（β=-0.0035，P=0.013）和臀围（β=-0.0028，P=0.044）相关。我们鉴定出多个细菌属，其相对丰度与肠内酯（26个属）和肠二醇（22个属，所有错误发现率<0.05）水平呈正相关，并构建了预测肠内酯的微生物评分和预测肠二醇的微生物评分，以反映宿主肠道微生物群产生肠木脂素的总体潜力。这两个评分均与较低的体重和CAP相关（均P<0.05）。预测肠内酯的微生物评分也与BFM（β=-0.1128，P=0.027）和VFL（β=-0.1265，P=0.044）呈负相关。我们的研究结果支持，调节宿主肠道微生物群可能是通过增强肠木脂素的产生来预防肥胖的一种潜在策略。
